دورية أكاديمية
Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach
| العنوان: | Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach |
|---|---|
| المؤلفون: | Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine |
| المساهمون: | Cancer Research UK |
| المصدر: | Organic & Biomolecular Chemistry ; volume 16, issue 11, page 1843-1850 ; ISSN 1477-0520 1477-0539 |
| بيانات النشر: | Royal Society of Chemistry (RSC) |
| سنة النشر: | 2018 |
| الوصف: | Structure-guided expansion of a fragment hit for the ATAD2 bromodomain enabled improvement in ATAD2 inhibition and selectivity over BRD4. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1039/c8ob00099a |
| الإتاحة: | https://doi.org/10.1039/c8ob00099aTest http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00099ATest |
| حقوق: | http://creativecommons.org/licenses/by/3.0Test/ |
| رقم الانضمام: | edsbas.7D482C96 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1039/c8ob00099a |
|---|