التفاصيل البيبلوغرافية
العنوان: |
EV-Mediated Chemoresistance in the Tumor Microenvironment: Is NF-κB a Player? |
المؤلفون: |
Di Vito Nolfi, Mauro, Vecchiotti, Davide, Flati, Irene, Verzella, Daniela, Di Padova, Monica, Alesse, Edoardo, Capece, Daria, Zazzeroni, Francesca |
المساهمون: |
Ministero dell’Istruzione, dell’Università e della Ricerca |
المصدر: |
Frontiers in Oncology ; volume 12 ; ISSN 2234-943X |
بيانات النشر: |
Frontiers Media SA |
سنة النشر: |
2022 |
المجموعة: |
Frontiers (Publisher - via CrossRef) |
مصطلحات موضوعية: |
Cancer Research, Oncology |
الوصف: |
Drug resistance is a major impediment to patient survival and remains the primary cause of unsuccessful cancer therapy. Drug resistance occurs in many tumors and is frequently induced by chemotherapy which triggers a defensive response both in cancerous and cancer-associated cells that constitute the tumor microenvironment (TME). Cell to cell communication within the TME is often mediated by extracellular vesicles (EVs) which carry specific tumor-promoting factors able to activate survival pathways and immune escape mechanisms, thus sustaining tumor progression and therapy resistance. NF-κB has been recognized as a crucial player in this context. NF-κB activation is involved in EVs release and EVs, in turn, can trigger NF-κB pathway activation in specific contexts, based on secreting cytotype and their specific delivered cargo. In this review, we discuss the role of NF-κB/EVs interplay that sustain chemoresistance in the TME by focusing on the molecular mechanisms that underlie inflammation, EVs release, and acquired drug resistance. |
نوع الوثيقة: |
article in journal/newspaper |
اللغة: |
unknown |
DOI: |
10.3389/fonc.2022.933922 |
DOI: |
10.3389/fonc.2022.933922/full |
الإتاحة: |
https://doi.org/10.3389/fonc.2022.933922Test |
حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
رقم الانضمام: |
edsbas.7CB93035 |
قاعدة البيانات: |
BASE |