دورية أكاديمية
Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis
| العنوان: | Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis |
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| المؤلفون: | Chapleau, M., Ossenkoppele, R., K., Xie, PCA International Work Group |
| المصدر: | The Lancet Neurology; 23(2), pp 168-177 (2024) ; ISSN: 1474-4422 |
| بيانات النشر: | Lancet Publishing Group |
| سنة النشر: | 2024 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Neurology, Alzheimer Disease, Amyloid beta-Peptides, Atrophy, Biomarkers, Cohort Studies, Demography, Female, Humans, Male, Middle Aged, amyloid beta protein, biological marker, dopamine transporter, fluorodeoxyglucose f 18, granulin, TAR DNA binding protein, tau protein, acalculia, advertising, agnosia, Article, autopsy, brain cortex atrophy, brain infarction, cerebral amyloid angiopathy, cerebrospinal fluid, cerebrovascular accident, clinical feature, cognitive defect |
| الوصف: | Background: Posterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker and neuropathological studies are scarce. We aimed to describe demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy in a large international cohort. Methods: We searched PubMed between database inception and Aug 1, 2021, for all published research studies on posterior cortical atrophy and related terms. We identified research centres from these studies and requested deidentified, individual participant data (published and unpublished) that had been obtained at the first diagnostic visit from the corresponding authors of the studies or heads of the research centres. Inclusion criteria were a clinical diagnosis of posterior cortical atrophy as defined by the local centre and availability of Alzheimer's disease biomarkers (PET or CSF), or a diagnosis made at autopsy. Not all individuals with posterior cortical atrophy fulfilled consensus criteria, being diagnosed using centre-specific procedures or before development of consensus criteria. We obtained demographic, clinical, biofluid, neuroimaging, and neuropathological data. Mean values for continuous variables were combined using the inverse variance meta-analysis method; only research centres with more than one participant for a variable were included. Pooled proportions were calculated for binary variables using a restricted maximum likelihood model. Heterogeneity was quantified using I2. Findings: We identified 55 research centres from 1353 papers, with 29 centres responding to our request. An additional seven centres were recruited by advertising via the Alzheimer's Association. We obtained data for 1092 individuals who were evaluated at 36 research centres in 16 countries, the other sites having not responded to our initial ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/4580ac8e-06c5-4ca5-8dc8-cfb7a3b7efa0Test; http://dx.doi.org/10.1016/S1474-4422Test(23)00414-3; scopus:85183038994; pmid:38267189 |
| DOI: | 10.1016/S1474-4422(23)00414-3 |
| الإتاحة: | https://doi.org/10.1016/S1474-4422Test(23)00414-3 https://lup.lub.lu.se/record/4580ac8e-06c5-4ca5-8dc8-cfb7a3b7efa0Test |
| رقم الانضمام: | edsbas.7CA8E949 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/S1474-4422(23)00414-3 |
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