دورية أكاديمية
Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats ; Efectos de la preformulación de Mimosa caesalpiniifolia sobre la barrera intestinal durante la colitis inducida por sulfato de dextrano sódico en ratas Wistar
| العنوان: | Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats ; Efectos de la preformulación de Mimosa caesalpiniifolia sobre la barrera intestinal durante la colitis inducida por sulfato de dextrano sódico en ratas Wistar |
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| المؤلفون: | Garnevi-Fávero, Aline, Silva, Karina Nascimento da, Ribeiro, Willian Rodrigues, Ferreira, Caroline Marcantonio, Sartorelli, Patrícia, Cardili, Leonardo, Cássia-Sinigaglia, Rita de, Pereira, Joice Naiara Bertaglia, Silva, Marcelo Aparecido da, Vilegas, Wagner, Silva, Marcelo José Dias, Paiotti, Ana Paula Ribeiro |
| المساهمون: | (UNIFESP) Universidade Federal de São Paulo, (UNIFAL-MG) Universidade Federal de Alfenas, (UNESP) Universidade Estadual Paulista Júlio de Mesquita Filho, Pereira, Joice Naiara Bertaglia|:Técnico|:(LEDM) Lab. Estratégico de Diagnóstico Molecular, (LEDM) Lab. Estratégico de Diagnóstico Molecular |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Mimosa, colitis, ulcerative, inflammatory bowel diseases, herbal medicine, ulcerosa, enfermedades, inflamatorias del intestino, medicina de hierbas |
| الوصف: | Introduction. Anti-inflammatories, immunosuppressants, and immunobiological are commonly used in the treatment of inflammatory bowel disease. However, some patients do not present an adequate response or lose effective response during the treatment. A recent study found a potential anti-inflammatory effect of the hydroalcoholic extract of Mimosa caesalpiniifolia on trinitrobenzene sulfonic acid-induced colitis in Wistar rats.Objective. To evaluate the effects of M. caesalpiniifolia pre-formulation on the intestinal barrier using dextran sulfate sodium-induced colitis model.Materials and methods. Leaf extracts were prepared in 70% ethanol and dried with a Buchi B19 Mini-spray dryer using 20% Aerosil® solution. Thirty-two male Wistar rats were randomized into four groups: basal control, untreated colitis, pre-formulation control (125 mg/kg/day), and colitis treated with pre-formulation (125 mg/kg/day). Clinical activity index was recorded daily and all rats were euthanized on the ninth day. Colon fragments were fixed and processed for histological and ultrastructural analyses.Stool samples were collected and processed for analysis of the short-chain fatty acid.Results. Treatment with the pre-formulation decreased the clinical activity (bloody diarrhea), inflammatory infiltrate, and the ulcers. Pre-formulation did not repair the epithelial barrier and there were no significant differences in the goblet cells index. There was a significant difference in butyrate levels in the rats treated with the pre-formulation.Conclusions. The pre-formulation minimized the clinical symptoms of colitis and intestinal inflammation, but did not minimize damage to the intestinal barrier. ; (CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior ; (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico ; (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo ; Introducción. Los antiinflamatorios, inmunosupresores e inmunobiológicos se utilizan comúnmente para tratar la enfermedad intestinal ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Biomédica Revista del Instituto Nacional de Salud; Biomédica; Garnevi-Fávero A, Silva KN, Ribeiro WR, Ferreira CM, Sartorelli P, Cardili L, et al. Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats. Biomédica. 2023 Jun; 43(2). doi:10.7705/biomedica.6611.; https://repositorio.butantan.gov.br/handle/butantan/4970Test; 43; v. 43, n. 2, jun. 2023; 2023 Jun; 43(2); BR78.1; IBProd |
| DOI: | 10.7705/biomedica.6611 |
| الإتاحة: | https://doi.org/10.7705/biomedica.6611Test https://repositorio.butantan.gov.br/handle/butantan/4970Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.7C9B8F59 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7705/biomedica.6611 |
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