دورية أكاديمية
Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome Parasites
| العنوان: | Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome Parasites |
|---|---|
| المؤلفون: | Kincaid-Smith, Julien, Picard, Marion A L, Cosseau, Céline, Boissier, Jérôme, Severac, Dany, Grunau, Christoph, Toulza, Eve |
| المصدر: | Kincaid-Smith J, Picard MAL, Cosseau C, et al. Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome Parasites. Genome Biology and Evolution . 2018;10(3):840-856. doi: 10.1093/gbe/evy037 |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2018 |
| المجموعة: | IST Austria Research Explorer (Institute of Science and Technology) |
| مصطلحات موضوعية: | ddc:570 |
| الوصف: | Schistosomes are the causative agents of schistosomiasis, a neglected tropical disease affecting over 230 million people worldwide.Additionally to their major impact on human health, they are also models of choice in evolutionary biology. These parasitic flatwormsare unique among the common hermaphroditic trematodes as they have separate sexes. This so-called “evolutionary scandal”displays a female heterogametic genetic sex-determination system (ZZ males and ZW females), as well as a pronounced adult sexualdimorphism. These phenotypic differences are determined by a shared set of genes in both sexes, potentially leading to intralocussexual conflicts. To resolve these conflicts in sexually selected traits, molecular mechanisms such as sex-biased gene expression couldoccur, but parent-of-origin gene expression also provides an alternative. In this work we investigated the latter mechanism, that is,genes expressed preferentially from either the maternal or the paternal allele, inSchistosoma mansonispecies. To this end, tran-scriptomes from male and female hybrid adults obtained by strain crosses were sequenced. Strain-specific single nucleotide poly-morphism (SNP) markers allowed us to discriminate the parental origin, while reciprocal crosses helped to differentiate parentalexpression from strain-specific expression. We identified genes containing SNPs expressed in a parent-of-origin manner consistentwith paternal and maternal imprints. Although the majority of the SNPs was identified in mitochondrial and Z-specific loci, theremaining SNPs found in male and female transcriptomes were situated in genes that have the potential to explain sexual differencesin schistosome parasites. Furthermore, we identified and validated four new Z-specific scaffolds. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/issn/1759-6653; info:eu-repo/semantics/altIdentifier/wos/000429483700013; https://research-explorer.ista.ac.at/record/5989Test; https://research-explorer.ista.ac.at/download/5989/5991Test |
| الإتاحة: | https://doi.org/10.1093/gbe/evy037Test https://research-explorer.ista.ac.at/record/5989Test https://research-explorer.ista.ac.at/download/5989/5991Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7C87F254 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |