دورية أكاديمية
Hospital discharges in urban sanitation systems: Long-term monitoring of wastewater resistome and microbiota in relationship to their eco-exposome
| العنوان: | Hospital discharges in urban sanitation systems: Long-term monitoring of wastewater resistome and microbiota in relationship to their eco-exposome |
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| المؤلفون: | Buelow, E, Rico, A, Gaschet, M, Lourenço, J, Kennedy, SP, Wiest, L, Ploy, M-C, Dagot, C |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2020 |
| المجموعة: | Oxford University Research Archive (ORA) |
| الوصف: | Wastewaters (WW) are important sources for the dissemination of antimicrobial resistance (AMR) into the environment. Hospital WW (HWW) contain higher loads of micro-pollutants and AMR markers than urban WW (UWW). Little is known about the long-term dynamics of H and U WW and the impact of their joined treatment on the general burden of AMR. Here, we characterized the resistome, microbiota and eco-exposome signature of 126 H and U WW samples treated separately for three years, and then mixed, over one year. Multi-variate analysis and machine learning revealed a robust signature for each WW with no significant variation over time before mixing, and once mixed, both WW closely resembled Urban signatures. We demonstrated a significant impact of pharmaceuticals and surfactants on the resistome and microbiota of H and U WW. Our results present considerable targets for AMR related risk assessment of WW. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://ora.ox.ac.uk/objects/uuid:4e9a25f5-f1c8-4dc0-a0b3-1314a83d1da1Test; https://doi.org/10.1016/j.wroa.2020.100045Test |
| DOI: | 10.1016/j.wroa.2020.100045 |
| الإتاحة: | https://doi.org/10.1016/j.wroa.2020.100045Test https://ora.ox.ac.uk/objects/uuid:4e9a25f5-f1c8-4dc0-a0b3-1314a83d1da1Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) |
| رقم الانضمام: | edsbas.7C84C9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.wroa.2020.100045 |
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