دورية أكاديمية
Immunological and Symptomatic Effects of Oral Intake of Transgenic Rice Containing 7 Linked Major T-Cell Epitopes from Japanese Cedar Pollen Allergens
| العنوان: | Immunological and Symptomatic Effects of Oral Intake of Transgenic Rice Containing 7 Linked Major T-Cell Epitopes from Japanese Cedar Pollen Allergens |
|---|---|
| المؤلفون: | Endo, Tomonori, Asaka, Daiya, Nakayama, Tsuguhisa, Saito, Shota, Kodama, Hiroki, Mitsuyoshi, Ryoto, Takaishi, Shinya, Sugimoto, Naoki, Omae, Sachiko, Takagi, Hidenori, Wakasa, Yuhya, Ozawa, Kenjiro, Takano, Makoto, Takaiwa, Fumio, Kojima, Hiromi, Saito, Saburo |
| المصدر: | International Archives of Allergy and Immunology ; volume 182, issue 2, page 109-119 ; ISSN 1018-2438 1423-0097 |
| بيانات النشر: | S. Karger AG |
| سنة النشر: | 2020 |
| الوصف: | Background: A rice-based peptide vaccine containing 7 linked human predominant T-cell epitopes (7Crp) derived from Japanese cedar (JC) pollen allergens, Cry j 1 and Cry j 2, was developed. Here, we examined the efficacy and safety of this transgenic rice in JC pollinosis patients. Methods: Transgenic rice (5, 20, and 80 g) was administered orally. We measured the T-cell proliferative activity against 7Crp, Cry j 1, and Cry j 2; the cytokine expression levels; and specific IgE and IgG4 production levels. In addition, the symptom and medication scores were monitored during the pollen season, and quality of life (QOL) was evaluated. Results: T-cell proliferative activities to Cry j 1, Cry j 2, and 7Crp were significantly depressed in a dose-dependent manner. Oral intake of 80 g transgenic rice for 20 weeks resulted in significant suppression of allergen-specific T-cell proliferation with downregulation of IL-13 and upregulation of IL-10 levels but no changes to specific IgE and IgG4 levels. The QOL symptom scores for allergic rhinitis were not significantly improved. Conclusions: Allergen-specific T-cell responses were significantly reduced by oral intake of transgenic rice in a dose-dependent manner. However, neither medication score nor QOL symptom scores could be improved during the JC pollen season with oral intake of transgenic rice for 20 weeks. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1159/000509996 |
| الإتاحة: | https://doi.org/10.1159/000509996Test https://karger.com/iaa/article-pdf/182/2/109/4020249/000509996.pdfTest |
| حقوق: | https://karger.com/pages/terms-and-conditionsTest ; https://karger.com/pages/terms-and-conditionsTest |
| رقم الانضمام: | edsbas.7BBA82A7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000509996 |
|---|