دورية أكاديمية
Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy
| العنوان: | Efficacy of subsequent treatments in patients with hormone-positive advanced breast cancer who had disease progression under CDK 4/6 inhibitor therapy |
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| المؤلفون: | Alkan, Ali, Nayir, Erdinc, Ugrakli, Muzaffer, Acar, Ömer, Erturk, Ismail, Aslan, Ferit, Sonmez, Özlem, Korkmaz, Taner, Karadag, Ibrahim, Kayikcioglu, Erkan, Oktem, Ilker Nihat, Eren, Tülay, Sakin, Abdullah, Demir, Hacer, Sakalar, Teoman, Karaçin, Cengiz, ÖksüzoÄŸlu, Berna, Demirci, Ayse, Keskinlınç, Merve, Köse Baytemur, Naziyet, Yılmaz, Funda, Selvi, OÄŸuzhan, Avsar, Esin, Paksoy, Nail, Demir, Necla, Turker, Sema, Bayram, Ertugrul, Celebi, Abduessamet, Yilmaz, Hatice, Kuzu, Omer Faruk, Kahraman, Seda, Gokmen, Ivo, Urul, Enes, Mocan, Eda Eylemer, Kalkan, Ziya, Yildirim, Nilgün, Akagunduz, Baran, Karakaya, Serdar, Kut, Engin, Teker, Fatih, Demirel, Burcin Cakan, Karaboyun, Kubilay, Almuradova, Elvina, Isik, Deniz, Okutur, Kerem, Oztosun, Bugra, Gulbagci, Burcu Belen, Kalender, Mehmet Emin, Sahin, Elif, Seyyar, Mustafa, Ozdemir, zlem, Kanitez, Metin, Dede, Isa, Gumus, Mahmut, Gokmen, Erhan, Ebinc, Senar, Aksoy, Sercan, Imamoglu, Goksen Inanc, Altinbas, Mustafa, Cetin, Bulent, Uluc, Basak Oyan, Er, Ozlem, Karadurmus, Nuri, Erdogan, Atike Pinar, Tanriverdi, Özgür, Cicin, Irfan, Sendur, Mehmet Ali Nahit, Oktay, Esin, Erdem, Dilek, Goksu, Sema Sezgin, Ergun, Yakup, Unal, Olcun Umit, Selcukbiricik, Fatih, Menekse, Serkan, Artac, Mehmet, Bayoglu, Ibrahim Vedat, Aydiner, Adnan, Salim, Derya Kivrak, Geredeli, Caglayan, Yavuzsen, Tugba, Dogan, Mutlu, Hacibekiroglu, Ilhan, Paydas, Semra, Oyman, Abdilkerim, Yaren, Arzu |
| بيانات النشر: | Bmc |
| سنة النشر: | 2023 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Advanced breast cancer, Cyclin-dependent kinase, Ribociclib, Palbociclib, Everolimus, Fulvestrant, Endocrine treatment, Hormonotherapy |
| الوصف: | Background There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which subsequent treatment oncologists prefer in patients with disease progression under CDKi. In addition, we aimed to show the effectiveness of systemic treatments after CDKi and whether there is a survival difference between hormonal treatments (monotherapy vs. mTOR-based). Methods A total of 609 patients from 53 centers were included in the study. Progression-free-survivals (PFS) of subsequent treatments (chemotherapy (CT, n:434) or endocrine therapy (ET, n:175)) after CDKi were calculated. Patients were evaluated in three groups as those who received CDKi in first-line (group A, n:202), second-line (group B, n: 153) and >= 3rd-line (group C, n: 254). PFS was compared according to the use of ET and CT. In addition, ET was compared as monotherapy versus everolimus-based combination therapy. Results The median duration of CDKi in the ET arms of Group A, B, and C was 17.0, 11.0, and 8.5 months in respectively; it was 9.0, 7.0, and 5.0 months in the CT arm. Median PFS after CDKi was 9.5 (5.0-14.0) months in the ET arm of group A, and 5.3 (3.9-6.8) months in the CT arm (p = 0.073). It was 6.7 (5.8-7.7) months in the ET arm of group B, and 5.7 (4.6-6.7) months in the CT arm (p = 0.311). It was 5.3 (2.5-8.0) months in the ET arm of group C and 4.0 (3.5-4.6) months in the CT arm (p = 0.434). Patients who received ET after CDKi were compared as those who received everolimus-based combination therapy versus those who received monotherapy ET: the median PFS in group A, B, and C was 11.0 vs. 5.9 (p = 0.047), 6.7 vs. 5.0 (p = 0.164), 6.7 vs. 3.9 (p = 0.763) months. Conclusion Physicians preferred CT rather than ET in patients with early progression under CDKi. It has been shown that subsequent ET after CDKi can be as effective as CT. It was also observed that better PFS could be achieved with the subsequent ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1471-2407 |
| العلاقة: | Bmc Cancer; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1186/s12885-023-10609-8Test; https://hdl.handle.net/11499/51122Test; 23; 2-s2.0-85147894207; WOS:000980043700010 |
| DOI: | 10.1186/s12885-023-10609-8 |
| الإتاحة: | https://doi.org/10.1186/s12885-023-10609-8Test https://hdl.handle.net/11499/51122Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.7BACC1AC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14712407 |
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| DOI: | 10.1186/s12885-023-10609-8 |