تقرير
The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1
| العنوان: | The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v.1 |
|---|---|
| المؤلفون: | Corfield, Elizabeth C, Frei, Oleksandr, Shadrin, Alexey A, Rahman, Zillur, Lin, Aihua, Athanasiu, Lavinia, Akdeniz, Bayram Cevdet, Hannigan, Laurie, Wootton, Robyn E, Austerberry, Chloe, Hughes, Amanda, Tesli, Martin, Westlye, Lars T, Stefánsson, Hreinn, Stefánsson, Kári, R. Njølstad, Pål, Magnus, Per, Davies, Neil M, Appadurai, Vivek, Hemani, Gibran, Hovig, Eivind, Zayats, Tetyana, Ask, Helga, Reichborn-Kjennerud, Ted, Andreassen, Ole A, Havdahl, Alexandra |
| المصدر: | Cold Spring Harbor Laboratory: Cold Spring Harbor (NY), USA. (2022) |
| بيانات النشر: | Cold Spring Harbor Laboratory |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | BACKRGROUND: The Norwegian Mother, Father, and Child Cohort Study (MoBa) is a population-based pregnancy cohort, which includes approximately 114,500 children, 95,200 mothers, and 75,200 fathers. Genotyping of MoBa has been conducted through multiple research projects, spanning several years; using varying selection criteria, genotyping arrays, and genotyping centres. MoBa contains numerous interrelated families, which necessitated the implementation of a family-based quality control (QC) pipeline that verifies and accounts for diverse types of relatedness. METHODS: The MoBaPsychGen pipeline, comprising pre-imputation QC, phasing, imputation, and post-imputation QC, was developed based on current best-practice protocols and implemented to account for the complex structure of the MoBa genotype data. The pipeline includes QC on both single nucleotide polymorphism (SNP) and individual level. Phasing and imputation were performed using the publicly available Haplotype Reference Consortium release 1.1 panel as a reference. Information from the Medical Birth Registry of Norway and MoBa questionnaires were used to identify biological sex, year of birth, reported parent-offspring (PO) relationships, and multiple births (only available in the offspring generation). RESULTS: In total, 207,569 unique individuals (90% of the unique individuals included in the study) and 6,981,748 SNPs passed the MoBaPsychGen pipeline. The relatedness checks performed throughout the pipeline allowed identification of within-generation and across-generation first-degree, second-degree, and third-degree relatives. The individuals passing post-imputation QC comprised 64,471 families ranging in size from singletons to 84 unique individuals (singletons are included as families as other family members may not have been genotyped, imputed, or passed post-imputation QC). The relationships identified include 287 monozygotic twin pairs, 22,884 full siblings, 117,004 PO pairs, 23,299 second-degree relative pairs, and 10,828 third-degree relative pairs. ... |
| نوع الوثيقة: | report |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10154727/1/2022.06.23.496289v2.full.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10154727Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10154727/1/2022.06.23.496289v2.full.pdfTest https://discovery.ucl.ac.uk/id/eprint/10154727Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.7B1E9D8D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |