كتاب
Stem Cells to Decipher the Physiological Roles of 5-HT2B Receptor Signaling
| العنوان: | Stem Cells to Decipher the Physiological Roles of 5-HT2B Receptor Signaling |
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| المؤلفون: | Baudry, Anne, Kellermann, Odile, Launay, Jean-Marie, Piétri, Mathéa, Schneider, B |
| المساهمون: | Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Luc Maroteaux, Laurent Monassier |
| المصدر: | 5-HT2B Receptors. From Molecular Biology to Clinical Applications https://hal.science/hal-03421339Test Luc Maroteaux Laurent Monassier. 5-HT2B Receptors. From Molecular Biology to Clinical Applications, 35, Springer International Publishing, pp.53-70, 2021, The Receptors, 978-3-030-55919-9. ⟨10.1007/978-3-030-55920-5_3⟩ |
| بيانات النشر: | HAL CCSD Springer International Publishing |
| سنة النشر: | 2021 |
| المجموعة: | Université Paris 13: HAL |
| مصطلحات موضوعية: | Serotonergic 2B receptor, signaling, stem cells, neuron, mineralized tissues, serotonin transporter, tissue-non specific alkaline phosphatase, miR-16, Prozac, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology |
| الوصف: | International audience ; The serotonergic 2B receptor (5-HT 2B R), expressed in the central nervous system and at the periphery, contributes to the regulation of several physiological processes such as cardio-vascular, pulmonary, bone and neuronal functions. Due to its multifaceted roles, signaling pathways and cell targets controlled by the 5-HT 2B R are still the subject of intensive research. Here, we review how exploiting the dynamics of differentiation of the 1C11 neuronal stem cell line allows to identify several 5-HT 2B R-coupled signaling pathways and targets, among which the serotonin transporter, involved in the homeostasis of serotonergic neurons and their adaptive response to selective serotonin-reuptake inhibitors (SSRIs) like fluoxetine (Prozac ®). In addition mesoblastic stem cell lines permit to show that along the osteogenic differentiation, the 5-HT 2B R controls the activity of the tissue-non-specific alkaline phosphatase, a major enzyme for bone formation. Finally the 5-HT 2B R expressed by pulpal stem cells takes part to natural tooth repair upon 5-HT release by injury-activated platelets. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| ردمك: | 978-3-030-55919-9 3-030-55919-X |
| العلاقة: | hal-03421339; https://hal.science/hal-03421339Test; https://hal.science/hal-03421339/documentTest; https://hal.science/hal-03421339/file/Baudry%20et%20al_Springer_The%20receptors_2021.pdfTest |
| DOI: | 10.1007/978-3-030-55920-5_3 |
| الإتاحة: | https://doi.org/10.1007/978-3-030-55920-5_3Test https://hal.science/hal-03421339Test https://hal.science/hal-03421339/documentTest https://hal.science/hal-03421339/file/Baudry%20et%20al_Springer_The%20receptors_2021.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.7AB184F1 |
| قاعدة البيانات: | BASE |
| ردمك: | 9783030559199 303055919X |
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| DOI: | 10.1007/978-3-030-55920-5_3 |