دورية أكاديمية
CaV1.3 as pacemaker channels in adrenal chromaffin cells: Specific role on exo- and endocytosis?
| العنوان: | CaV1.3 as pacemaker channels in adrenal chromaffin cells: Specific role on exo- and endocytosis? |
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| المؤلفون: | COMUNANZA, Valentina, MARCANTONI, Andrea, VANDAEL, DAVID HENRI FRANCOIS, MAHAPATRA, Satyajit, GAVELLO, DANIELA, CARABELLI, Valentina, CARBONE, Emilio, Navarro Tableros V |
| المساهمون: | Comunanza V, Marcantoni A, Vandael DH, Mahapatra S, Gavello D, Navarro-Tableros V, Carabelli V, Carbone E |
| سنة النشر: | 2010 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | canali del calcio, canali del potassio, secrezione, endocitosi, potanziali d'azione spontanei |
| الوصف: | Voltage-gated L-type calcium channels (LTCCs) are expressed in adrenal chromaffin cells. Besides shaping the action potential (AP), LTCCs are involved in the excitation-secretion coupling controlling catecholamine release and in Ca (2+) -dependent vesicle retrieval. Of the two LTCCs expressed in chromaffin cells (CaV1.2 and CaV1.3), CaV1.3 possesses the prerequisites for pacemaking spontaneously firing cells: low-threshold, steep voltage-dependence of activation and slow inactivation. By using CaV1 .3 (-/-) KO mice and the AP-clamp it has been possible to resolve the time course of CaV1.3 pacemaker currents, which is similar to that regulating substantia nigra dopaminergic neurons. In mouse chromaffin cells CaV1.3 is coupled to fast-inactivating BK channels within membrane nanodomains and controls AP repolarization. The ability to carry subthreshold Ca (2+) currents and activate BK channels confers to CaV1.3 the unique feature of driving Ca (2+) loading during long interspike intervals and, possibly, to control the Ca (2+) -dependent exocytosis and endocytosis processes that regulate catecholamine secretion and vesicle recycling. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/21084859; info:eu-repo/semantics/altIdentifier/wos/WOS:000287661000003; volume:4; issue:6; firstpage:440; lastpage:446; numberofpages:7; journal:CHANNELS; http://hdl.handle.net/2318/81565Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-78650830600; http://www.personalweb.unito.it/emilio.carboneTest/ |
| DOI: | 10.4161/chan.4.6.12866 |
| الإتاحة: | https://doi.org/10.4161/chan.4.6.12866Test http://hdl.handle.net/2318/81565Test http://www.personalweb.unito.it/emilio.carboneTest/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7AA5441 |
| قاعدة البيانات: | BASE |
| DOI: | 10.4161/chan.4.6.12866 |
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