صورة
Image_2_The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study.TIF
| العنوان: | Image_2_The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study.TIF |
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| المؤلفون: | Subeen Hong, Byung Soo Kang, Oyoung Kim, Sangeun Won, Hyeon Soo Kim, Jeong Ha Wie, Jae Eun Shin, Sae Kyung Choi, Yun Sung Jo, Yeon Hee Kim, Mihi Yang, Huiwon Kang, Dong-Wook Lee, In Yang Park, Joong Shin Park, Hyun Sun Ko |
| سنة النشر: | 2024 |
| المجموعة: | Frontiers: Figshare |
| مصطلحات موضوعية: | Mental Health Nursing, Midwifery, Nursing not elsewhere classified, Aboriginal and Torres Strait Islander Health, Aged Health Care, Care for Disabled, Community Child Health, Environmental and Occupational Health and Safety, Epidemiology, Family Care, Health and Community Services, Health Care Administration, Health Counselling, Health Information Systems (incl. Surveillance), Health Promotion, Preventive Medicine, Primary Health Care, Public Health and Health Services not elsewhere classified, Nanotoxicology, Health and Safety, Medicine, Nursing and Health Curriculum and Pedagogy, endocrine disruptors, bisphenol-A, monoethyl phthalates, perfluorooctanoic acid, fetal growth restriction, placental insufficiency |
| الوصف: | Recent evidence has revealed associations between endocrine-disrupting chemicals (EDCs) and placental insufficiency due to altered placental growth, syncytialization, and trophoblast invasion. However, no epidemiologic study has reported associations between exposure to EDCs and asymmetric fetal growth restriction (FGR) caused by placenta insufficiency. The aim of this study was to evaluate the association between EDC exposure and asymmetric FGR. This was a prospective cohort study including women admitted for delivery to the Maternal Fetal Center at Seoul St. Mary’s Hospital between October 2021 and October 2022. Maternal urine and cord blood samples were collected, and the levels of bisphenol-A (BPA), monoethyl phthalates, and perfluorooctanoic acid in each specimen were analyzed. We investigated linear and non-linear associations between the levels of EDCs and fetal growth parameters, including the head circumference (HC)/abdominal circumference (AC) ratio as an asymmetric parameter. The levels of EDCs were compared between fetuses with and without asymmetric FGR. Of the EDCs, only the fetal levels of BPA showed a linear association with the HC/AC ratio after adjusting for confounding variables (β = 0.003, p < 0.05). When comparing the normal growth and asymmetric FGR groups, the asymmetric FGR group showed significantly higher maternal and fetal BPA levels compared to the normal growth group (maternal urine BPA, 3.99 μg/g creatinine vs. 1.71 μg/g creatinine [p < 0.05]; cord blood BPA, 1.96 μg/L vs. −0.86 μg/L [p < 0.05]). In conclusion, fetal exposure levels of BPA show linear associations with asymmetric fetal growth patterns. High maternal and fetal exposure to BPA might be associated with asymmetric FGR. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/figure/Image_2_The_associations_between_maternal_and_fetal_exposure_to_endocrine-disrupting_chemicals_and_asymmetric_fetal_growth_restriction_a_prospective_cohort_study_TIF/25584462Test |
| DOI: | 10.3389/fpubh.2024.1351786.s004 |
| الإتاحة: | https://doi.org/10.3389/fpubh.2024.1351786.s004Test https://figshare.com/articles/figure/Image_2_The_associations_between_maternal_and_fetal_exposure_to_endocrine-disrupting_chemicals_and_asymmetric_fetal_growth_restriction_a_prospective_cohort_study_TIF/25584462Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.7A8F1683 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fpubh.2024.1351786.s004 |
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