دورية أكاديمية
The role of basolateral amygdala orexin 1 receptors on the modulation of pain and psychosocial deficits in nitroglycerin-induced migraine model in adult male rats
| العنوان: | The role of basolateral amygdala orexin 1 receptors on the modulation of pain and psychosocial deficits in nitroglycerin-induced migraine model in adult male rats |
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| المؤلفون: | Askari-Zahabi, Khadijeh, Abbasnejad, Mehdi, Kooshki, Razieh, Raoof, Maryam, Esmaeili-Mahani, Saeed, Pourrahimi, Ali Mohammad, Zamyad, Mahnaz |
| المصدر: | Askari-Zahabi , K , Abbasnejad , M , Kooshki , R , Raoof , M , Esmaeili-Mahani , S , Pourrahimi , A M & Zamyad , M 2022 , ' The role of basolateral amygdala orexin 1 receptors on the modulation of pain and psychosocial deficits in nitroglycerin-induced migraine model in adult male rats ' , Korean Journal of Pain , vol. 35 , no. 1 , pp. 22-32 . https://doi.org/10.3344/kjp.2022.35.1.22Test |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Amygdala, Anxiety, Basolateral nuclear complex, Hyperalgesia, Migraine disorders, Nitroglycerin, Orexin receptor antagonists, Orexin receptors, Orexins, Rats |
| الوصف: | Background: Migraine headaches have been associated with sensory hyperactivity and anomalies in social/emotional responses. The main objective of this study was to evaluate the potential involvement of orexin 1 receptors (Orx1R) within the basolateral amygdala (BLA) in the modulation of pain and psychosocial dysfunction in a nitroglycerin (NTG)-induced rat model of migraine. Methods: Adult male Wistar rats were injected with NTG (5 mg/kg, intraperitoneal) every second day over nine days to induce migraine. The experiments were done in the following six groups (6 rats per group): untreated control, NTG, NTG plus vehicle, and NTG groups that were post-treated with intra-BLA microinjection of Orx1R antagonist SB-334867 (10, 20, and 40 nM). Thermal hyperalgesia was assessed using the hot plate and tail-flick tests. Moreover, the elevated plus maze (EPM) and open field (OF) tests were used to assess anxiety-like behaviors. The animals' sociability was evaluated using the three-chamber social task. The NTG-induced photophobia was assessed using a light-dark box. Results: We observed no change in NTG-induced thermal hyperalgesia following administration of SB-334867 (10, 20, and 40 nM). However, SB-334867 (20 and 40 nM) aggravated the NTG-induced anxiogenic responses in both the EPM and OF tasks. The NTG-induced social impairment was overpowered by SB-334867 at all doses. Time spent in the dark chamber of light-dark box was significantly increased in rats treated with SB-334867 (20 and 40 nM/rat). Conclusions: The findings suggest a role for Orx1R within the BLA in control comorbid affective complaints with migraine in rats. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.vu.nl/en/publications/760ced1e-0c88-42a0-a1d4-2e2da75f6b41Test |
| DOI: | 10.3344/kjp.2022.35.1.22 |
| الإتاحة: | https://doi.org/10.3344/kjp.2022.35.1.22Test https://research.vu.nl/en/publications/760ced1e-0c88-42a0-a1d4-2e2da75f6b41Test https://hdl.handle.net/1871.1/760ced1e-0c88-42a0-a1d4-2e2da75f6b41Test http://www.scopus.com/inward/record.url?scp=85123546018&partnerID=8YFLogxKTest http://www.scopus.com/inward/citedby.url?scp=85123546018&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.79D49DAD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3344/kjp.2022.35.1.22 |
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