دورية أكاديمية
Cytokines in primary headache disorders: a systematic review and meta-analysis
| العنوان: | Cytokines in primary headache disorders: a systematic review and meta-analysis |
|---|---|
| المؤلفون: | Musubire, Abdu Kisekka, Cheema, Sanjay, Ray, Jason C, Hutton, Elspeth J, Matharu, Manjit |
| المصدر: | The Journal of Headache and Pain , 24 , Article 36. (2023) |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Cytokine, Immunology, Migraine disorders, Neurogenic inflammation, Tension-type headache, Humans, Cytokines, Tumor Necrosis Factor-alpha, Cluster Headache, Interleukin-8, Inflammation |
| الوصف: | BACKGROUND: The role of inflammation and cytokines in the pathophysiology of primary headache disorders is uncertain. We performed a systematic review and meta-analysis to synthesise the results of studies comparing peripheral blood cytokine levels between patients with migraine, tension-type headache, cluster headache, or new daily persistent headache (NDPH), and healthy controls; and in migraine between the ictal and interictal stages. METHODS: We searched PubMed/Medline and Embase from inception until July 2022. We included original research studies which measured unstimulated levels of any cytokines in peripheral blood using enzyme-linked immunosorbent assay or similar assay. We assessed risk of bias using the Newcastle-Ottawa Quality Assessment Scale. We used random effects meta-analysis with inverse variance weighted average to calculate standardised mean difference (SMD), 95% confidence intervals, and heterogeneity for each comparison. This study is registered with PROSPERO (registration number CRD42023393363). No funding was received for this study. RESULTS: Thirty-eight studies, including 1335 patients with migraine (32 studies), 302 with tension-type headache (nine studies), 42 with cluster headache (two studies), and 1225 healthy controls met inclusion criteria. Meta-analysis showed significantly higher interleukin (IL)-6 (SMD 1.07, 95% CI 0.40-1.73, p = 0.002), tumour necrosis factor (TNF)-α (SMD 0.61, 95% CI 0.14-1.09, p = 0.01), and IL-8 (SMD 1.56, 95% CI 0.03-3.09, p = 0.04), in patients with migraine compared to healthy controls, and significantly higher interleukin-1β (IL-1β) (SMD 0.34, 95% CI 0.06-0.62, p = 0.02) during the ictal phase of migraine compared to the interictal phase. Transforming growth factor (TGF)-β (SMD 0.52, 95% CI 0.18-0.86, p = 0.003) and TNF-α (SMD 0.64, 95% CI 0.33-0.96, p = 0.0001) were both higher in patients with tension-type headache than controls. CONCLUSIONS: The higher levels of the proinflammatory cytokines IL-6, IL-8 and TNF-α in migraine compared to controls, and ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10168076/1/Cytokines%20in%20primary%20headache%20disorders%20a%20systematic%20review%20and%20meta-analysis.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10168076Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10168076/1/Cytokines%20in%20primary%20headache%20disorders%20a%20systematic%20review%20and%20meta-analysis.pdfTest https://discovery.ucl.ac.uk/id/eprint/10168076Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.79578AB3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |