دورية أكاديمية
The HAPSTR2 retrogene buffers stress signaling and resilience in mammals
| العنوان: | The HAPSTR2 retrogene buffers stress signaling and resilience in mammals |
|---|---|
| المؤلفون: | Amici, David R., Cingoz, Harun, Alasady, Milad J., Alhayek, Sammy, Phoumyvong, Claire M., Sahni, Nidhi, Yi, S. Stephen, Mendillo, Marc L. |
| المساهمون: | U.S. Department of Health & Human Services | National Institutes of Health, Cancer Prevention and Research Institute of Texas, Susan G. Komen, American Cancer Society, Sidney Kimmel Foundation, Lynn Sage Scholar Award |
| المصدر: | Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary |
| الوصف: | We recently identified HAPSTR1 (C16orf72) as a key component in a novel pathway which regulates the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, and protein misfolding. Here, we identify a functional paralog to HAPSTR1: HAPSTR2. HAPSTR2 formed early in mammalian evolution, via genomic integration of a reverse transcribed HAPSTR1 transcript, and has since been preserved under purifying selection. HAPSTR2, expressed primarily in neural and germline tissues and a subset of cancers, retains established biochemical features of HAPSTR1 to achieve two functions. In normal physiology, HAPSTR2 directly interacts with HAPSTR1, markedly augmenting HAPSTR1 protein stability in a manner independent from HAPSTR1’s canonical E3 ligase, HUWE1. Alternatively, in the context of HAPSTR1 loss, HAPSTR2 expression is sufficient to buffer stress signaling and resilience. Thus, we discover a mammalian retrogene which safeguards fitness. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-022-35697-1 |
| الإتاحة: | https://doi.org/10.1038/s41467-022-35697-1Test https://www.nature.com/articles/s41467-022-35697-1.pdfTest https://www.nature.com/articles/s41467-022-35697-1Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.78D26185 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-022-35697-1 |
|---|