دورية أكاديمية
Epstein-Barr Virus Coinfection and Recombination in Non-Human Immunodeficiency Virus-Associated Oral Hairy Leukoplakia
| العنوان: | Epstein-Barr Virus Coinfection and Recombination in Non-Human Immunodeficiency Virus-Associated Oral Hairy Leukoplakia |
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| المؤلفون: | Walling, Dennis M., Clark, Nina M., Markovitz, David M., Frank, Thomas S., Braun, Daniel K., Eisenberg, Ellen, Krutchkoff, David J., Felix, David H., Raab-Traub, Nancy |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1995 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Major Articles |
| الوصف: | Human immunodeficiency virus-associated oral hairy leukoplakia (HLP) is characterized by coinfection with multiple types and strains of Epstein-Barr virus (EBV) and recombination within the EBV genome. HIV-seronegative immunosuppressed and immunocompetent patients with HLP were examined to determine the pathogenic contribution of EBV coinfection and recombination to the development of HLP. Multiple coinfecting EBV strains were detected in both HLP specimens and peripheral blood lymphocytes (PBL) of HIV-seronegative persons with HLP. One specific EBV strain was detected in HLP specimens from 3 of 4 patients. Also, viral recombination during productive replication within HLP generated variants of the latent membrane protein-l (LMP-l) and nuclear antigen-Z (EBNA-2) genes. Some variants were also detected within PBL. Thus, EBV coinfection and recombination are consistent findings in persons with HLP regardless of immune status. Virally mediated determinants may be important features of EBV pathogenesis. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://jid.oxfordjournals.org/cgi/content/short/171/5/1122Test; http://dx.doi.org/10.1093/infdis/171.5.1122Test |
| DOI: | 10.1093/infdis/171.5.1122 |
| الإتاحة: | https://doi.org/10.1093/infdis/171.5.1122Test http://jid.oxfordjournals.org/cgi/content/short/171/5/1122Test |
| حقوق: | Copyright (C) 1995, Infectious Diseases Society of America |
| رقم الانضمام: | edsbas.78BA789F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/171.5.1122 |
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