التفاصيل البيبلوغرافية
| العنوان: |
Controversial Role of the Immune Checkpoint OX40L Expression on Platelets in Breast Cancer Progression |
| المؤلفون: |
Rittig, Susanne M., Lutz, Martina S., Clar, Kim L., Zhou, Yanjun, Kropp, Korbinian N., Koch, André, Hartkopf, Andreas D., Hinterleitner, Martina, Zender, Lars, Salih, Helmut R., Maurer, Stefanie, Hinterleitner, Clemens |
| المساهمون: |
Deutsche Forschungsgemeinschaft, Wilhelm Sander-Stiftung, Deutsche Krebshilfe |
| المصدر: |
Frontiers in Oncology ; volume 12 ; ISSN 2234-943X |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2022 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| الوصف: |
In conventional T cells, OX40 has been identified as a major costimulating receptor augmenting survival and clonal expansion of effector and memory T cell populations. In regulatory T cells, (Treg) OX40 signaling suppresses cellular activity and differentiation. However, clinical trials investigating OX40 agonists to enhance anti-tumor immunity, showed only limited success so far. Here we show that platelets from breast cancer patients express relevant levels of OX40L and platelet OX40L (pOX40L) inversely correlates with platelet-expressed immune checkpoint molecules GITRL (pGITRL) and TACI (pTACI). While high expression of pOX40L correlates with T and NK cell activation, elevated pOX40L levels identify patients with higher tumor grades, the occurrence of metastases, and shorter recurrence-free survival (RFS). Of note, OX40 mRNA levels in breast cancer correlate with enhanced expression of anti-apoptotic, immune-suppressive, and tumor-promoting mRNA gene signatures. Our data suggest that OX40L on platelets might play counteracting roles in cancer and anti-tumor immunity. Since pOX40L reflects disease relapse better than the routinely used predictive markers CA15-3, CEA, and LDH, it could serve as a novel biomarker for refractory disease in breast cancer. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fonc.2022.917834 |
| DOI: |
10.3389/fonc.2022.917834/full |
| الإتاحة: |
https://doi.org/10.3389/fonc.2022.917834Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.78A10A41 |
| قاعدة البيانات: |
BASE |
