دورية أكاديمية
Variability of vaccine responsiveness in early life
| العنوان: | Variability of vaccine responsiveness in early life |
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| المؤلفون: | Pichichero, Michael E |
| المصدر: | Rochester Regional Health authored publications and proceedings |
| بيانات النشر: | RocScholar |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Antibiotics, Antibody, Antigen presenting cells, B cells T cells, Breast feeding, Caesarian section, Metabolome, Microbiome, Vaccination, Infant, Child, Female, Pregnancy, Humans, Newborn, Vaccines, Microbiota, Immunity, Cellular, Medicine and Health Sciences |
| الوصف: | Vaccinations in early life elicit variable antibody and cellular immune responses, sometimes leaving fully vaccinated children unprotected against life-threatening infectious diseases. Specific immune cell populations and immune networks may have a critical period of development and calibration in a window of opportunity occurring during the first 100 days of early life. Among the early life determinants of vaccine responses, this review will focus on modifiable factors involving development of the infant microbiota and metabolome: antibiotic exposure, breast versus formula feeding, and Caesarian section versus vaginal delivery of newborns. How microbiota may serve as natural adjuvants for vaccine responses and how microbiota-derived metabolites influence vaccine responses are also reviewed. Early life poor vaccine responsiveness can be linked to increased infection susceptibility because both phenotypes share similar immunity dysregulation profiles. An early life pre-vaccination endotype, when interventions have the highest potential for success, should be sought that predicts vaccine response trajectories. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://scholar.rochesterregional.org/rrhpubs/2117Test; https://doi.org/10.1016/j.cellimm.2023.104777Test |
| DOI: | 10.1016/j.cellimm.2023.104777 |
| الإتاحة: | https://doi.org/10.1016/j.cellimm.2023.104777Test https://scholar.rochesterregional.org/rrhpubs/2117Test |
| رقم الانضمام: | edsbas.7891FFDD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cellimm.2023.104777 |
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