دورية أكاديمية
Mechanism and Clinical Importance of Respiratory Failure Induced by Anticholinesterases
| العنوان: | Mechanism and Clinical Importance of Respiratory Failure Induced by Anticholinesterases |
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| المؤلفون: | Ivosevic Anita, Miletic Natasa, Vulovic Maja, Vujkovic Zoran, Bursac Snjezana Novakovic, Cetkovic Slavko S., Skrbic Ranko, Stojiljkovic Milos P. |
| المصدر: | Serbian Journal of Experimental and Clinical Research, Vol 18, Iss 4, Pp 349-355 (2017) |
| بيانات النشر: | Sciendo |
| سنة النشر: | 2017 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | anticholinesterase, acetylcholinesterase, acetylcholine, atropine, oxime, diazepam, respiratory depression, muscarinic receptors, nicotinic receptors, Medicine |
| الوصف: | Respiratory failure is the predominant cause of death in humans and animals poisoned with anticholinesterases. Organophosphorus and carbamate anticholinesterases inhibit acetylcholinesterase irreversibly and reversibly, respectively. Some of them contain a quaternary atom that makes them lipophobic, limiting their action at the periphery, i.e. outside the central nervous system. They impair respiratory function primarily by inducing a desensitization block of nicotinic receptors in the neuromuscular synapse. Lipophilic anticholinesterases inhibit the acetylcholinesterase both in the brain and in other tissues, including respiratory muscles. Their doses needed for cessation of central respiratory drive are significantly less than doses needed for paralysis of the neuromuscular transmission. Antagonist of muscarinic receptors atropine blocks both the central and peripheral muscarinic receptors and effectively antagonizes the central respiratory depression produced by anticholinesterases. To manage the peripheral nicotinic receptor hyperstimulation phenomena, oximes as acetylcholinesterase reactivators are used. Addition of diazepam is useful for treatment of seizures, since they are cholinergic only in their initial phase and can contribute to the occurrence of central respiratory depression. Possible involvement of central nicotinic receptors as well as the other neurotransmitter systems – glutamatergic, opioidergic – necessitates further research of additional antidotes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1820-8665 2335-075X |
| العلاقة: | https://doi.org/10.1515/sjecr-2016-0047Test; https://doaj.org/toc/1820-8665Test; https://doaj.org/toc/2335-075XTest; https://doaj.org/article/515682e11e7648c7ab4db7c25927183aTest |
| DOI: | 10.1515/sjecr-2016-0047 |
| الإتاحة: | https://doi.org/10.1515/sjecr-2016-0047Test https://doaj.org/article/515682e11e7648c7ab4db7c25927183aTest |
| رقم الانضمام: | edsbas.786158 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18208665 2335075X |
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| DOI: | 10.1515/sjecr-2016-0047 |