دورية أكاديمية
Incidence and Durability of SARS-CoV-2 Antibodies in Patients with Cancer and Health Care Workers following the First Wave of the Pandemic
| العنوان: | Incidence and Durability of SARS-CoV-2 Antibodies in Patients with Cancer and Health Care Workers following the First Wave of the Pandemic |
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| المؤلفون: | Lai, Catherine, Potosky, Arnold L., McGuire, Colleen, Lobo, Tania, Ahn, Jaeil, Haddad, Bassem R., Richards, Ernest W., Anand, Palka, Wright, Kristen, Christenson, Robert H., Boyle, Lisa, Goy, Andre, Atkins, Michael B. |
| المصدر: | Journal of Oncology ; 2022 ; 1 ; 8 |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2022 |
| المجموعة: | UMB Digital Archive (University of Maryland, Baltimore) |
| مصطلحات موضوعية: | Covid-19, SARS-CoV-2 Antibodies |
| الوصف: | Background: Patients with cancer and health care workers (HCW) are at higher risk for SARS-CoV-2 infection. There are limited data regarding the rate of symptomatic versus asymptomatic infection and subsequent seropositivity in both populations. Methods: We performed a prospective study of patients and HCW across two institutions during the first wave of the pandemic to analyze the prevalence of SARS-CoV-2 antibodies, the extent of associated symptoms, and durability of serologic response. Results: In 1,953 persons (733 patients and 1,220 HCW), overall seropositivity rates for 3.1% patients (95% CI 2.0-4.7) and 3.7% HCW (95% CI 2.7-4.9, p=0.520), were similar. Each institutions' seropositivity rates were numerically higher in HCW than patients. Non-Hispanic Whites and Asians had lower antibody rates (2.8%, 95% CI 2.0-3.8 and 3.3%, 95% CI 1.2-7.0) compared to Hispanics (6.9%, 95% CI 3.4-12.4) and non-Hispanic Blacks (5.9%, 95% CI 3.3-9.7), p < 0.001. Among persons with a positive SARS-CoV-2 antibody, 87% of patients and 56% of HCW did not recall having had a fever. Among HCW, administrative and technical personnel were most likely to be seropositive. The rate of persistent seropositivity at 3 months was similar between patients and HCW and was not influenced by the reporting of fever, cancer type, or therapy. Conclusion: These data suggest that patients are not at higher risk for febrile SARS-CoV-2 infections or more transient immunity than HCWs. Furthermore, racial differences and lack of association with the extent of HCW contact with COVID-19 patients suggest that community rather than hospital virus exposure was a source of many infections. ; Georgetown University ; https://doi.org/10.1155/2022/8798306Test |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Journal of Oncology; http://hdl.handle.net/10713/18143Test |
| DOI: | 10.1155/2022/8798306 |
| الإتاحة: | https://doi.org/10.1155/2022/8798306Test http://hdl.handle.net/10713/18143Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.77E7E143 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1155/2022/8798306 |
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