التفاصيل البيبلوغرافية
| العنوان: |
Role of CYR61 in psoriatic lesional and perilesional skin: A clinical and immunohistochemical study |
| المؤلفون: |
Shehata, Wafaa Ahmed, Maraee, Alaa Hassan, Abdo, Eman Essam, Hemida, Aiat Shaban |
| المصدر: |
Journal of Cosmetic Dermatology ; volume 20, issue 9, page 2981-2988 ; ISSN 1473-2130 1473-2165 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2021 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background Psoriasis is considered as an immune‐mediated disorder with significant epidermal hyperplasia and inflammation. Cysteine‐rich angiogenic inducer 61 (CYR61), known as CCN family member 1 (CCN1), plays an important role in cell proliferation and neovascularization which may trigger psoriasis development. Aims This study aimed to assess the immunostaining of CYR61 in psoriatic skin (lesional and perilesional) compared to control skin. Patients/Methods This is a case‐control study. The Psoriasis Area and Severity Index (PASI) was used to evaluate disease severity. A punch biopsy was taken from psoriatic skin lesions (30), perilesional (30) skin, and matched site of controls (20). The pathological and immunostaining assessments of CYR61 were conducted. Results There was a significant gradual progressive overexpression of CYR61 in keratinocytes from control skin to perilesional and lesional psoriatic skin ( P = .00). Moreover, lesional psoriatic skin showed overexpression of CYR61 in inflammatory cells in the dermis than controls. CYR61 expression (lesional epidermis) revealed a significant positive correlation with the PASI score ( r = .63; P = .00). There was a significant relationship between intensity and H‐core of CYR61 in the lesional psoriatic epidermis with joint affection. Conclusion CYR61 may trigger epidermal hyperplasia and potentiate inflammatory infiltration in psoriasis vulgaris patients, and therapies targeting CYR61 may be effective in the management of psoriasis vulgaris. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/jocd.13947 |
| الإتاحة: |
https://doi.org/10.1111/jocd.13947Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.77620A36 |
| قاعدة البيانات: |
BASE |
