دورية أكاديمية
No impact of NRAS mutation on features of primary and metastatic melanoma or on outcomes of checkpoint inhibitor immunotherapy: An italian melanoma intergroup (IMI) study
| العنوان: | No impact of NRAS mutation on features of primary and metastatic melanoma or on outcomes of checkpoint inhibitor immunotherapy: An italian melanoma intergroup (IMI) study |
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| المؤلفون: | Guida M., Bartolomeo N., Quaglino P., Madonna G., Pigozzo J., Di Giacomo A. M., Minisini A. M., Tucci M., Spagnolo F., Occelli M., Ridolfi L., Queirolo P., De Risi I., Quaresmini D., Gambale E., Sileni V. C., Ascierto P. A., Stigliano L., Strippoli S. |
| المساهمون: | Guida, M., Bartolomeo, N., Quaglino, P., Madonna, G., Pigozzo, J., Di Giacomo, A. M., Minisini, A. M., Tucci, M., Spagnolo, F., Occelli, M., Ridolfi, L., Queirolo, P., De Risi, I., Quaresmini, D., Gambale, E., Sileni, V. C., Ascierto, P. A., Stigliano, L., Strippoli, S. |
| سنة النشر: | 2021 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| مصطلحات موضوعية: | Checkpoint inhibitor, Immunotherapy, Melanoma, NRAS mutation |
| الوصف: | Neuroblastoma RAS Viral Oncogen Homolog (NRAS) mutant melanoma is usually considered more aggressive and more responsive to checkpoint inhibitor immunotherapy (CII) than NRAS wildtype. We retrospectively recruited 331 metastatic melanoma patients treated with CII as first line: 162 NRAS-mutant/BRAF wild-type and 169 wt/wt. No substantial differences were observed among the two cohorts regarding the melanoma onset and disease-free interval. Also, overall response to CII, progression-free survival and overall survival were similar in the two groups. Therefore, our data do not show increased aggressiveness and higher responsiveness to CII in NRAS-mutant melanoma. The controversy in the published data could be due to different patient characteristics and treatment heterogeneity. We believe our data adds evidence to clear up these controversial issues. Aims: It is debated whether the NRAS-mutant melanoma is more aggressive than NRAS wildtype. It is equally controversial whether NRAS-mutant metastatic melanoma (MM) is more responsive to checkpoint inhibitor immunotherapy (CII). 331 patients treated with CII as first-line were retrospectively recruited: 162 NRAS-mutant/BRAF wild-type (mut/wt) and 169 wt/wt. We compared the two cohorts regarding the characteristics of primary and metastatic disease, disease-free interval (DFI) and outcome to CII. No substantial differences were observed between the two groups at melanoma onset, except for a more frequent ulceration in the wt/wt group (p = 0.03). Also, the DFI was very similar in the two cohorts. In advanced disease, we only found lung and brain progression more frequent in the wt/wt group. Regarding the outcomes to CII, no significant differences were reported in overall response rate (ORR), disease control rate (DCR), progression free survival (PFS) or overall survival (OS) (42% versus 37%, 60% versus 59%, 12 (95% CI, 7-18) versus 9 months (95% CI, 6-16) and 32 (95% CI, 23-49) versus 27 months (95% CI, 16-35), respectively). Irrespectively of mutational status, a ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33530579; info:eu-repo/semantics/altIdentifier/wos/WOS:000615004300001; volume:13; issue:3; firstpage:1; lastpage:15; numberofpages:15; journal:CANCERS; https://hdl.handle.net/11365/1233247Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099938582; https://www.mdpi.com/2072-6694/13/3/475Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865301Test/ |
| DOI: | 10.3390/cancers13030475 |
| الإتاحة: | https://doi.org/10.3390/cancers13030475Test https://hdl.handle.net/11365/1233247Test https://www.mdpi.com/2072-6694/13/3/475Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865301Test/ |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.774901E5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers13030475 |
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