دورية أكاديمية
Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer
| العنوان: | Systemic Inflammatory Biomarkers as Surrogate Markers for Stage in Colon Cancer |
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| المؤلفون: | Uludag, S.S., Sanli, A.N., Zengin, A.K., Ozcelik, M.F. |
| بيانات النشر: | SAGE Publications Inc. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | colon cancer, hematological indices, prognostic nutritional index, stage, systemic inflammatory biomarkers, albumin, biological marker, C reactive protein, lactate dehydrogenase, albuminoid, adult, Article, blood cell ratio, cancer patient, cancer staging, CRP albumin ratio, disease marker, human, lymphocyte, lymphocyte CRP ratio, lymphocyte monocyte ratio, major clinical study, medical parameters, monocyte, neutrophil, neutrophil albumin ratio, neutrophil lymphocyte ratio, neutrophil monocyte ratio, platelet lymphocyte ratio, systemic inflammatory response syndrome |
| الوصف: | Background: This study aimed to investigate whether the systemic inflammatory parameters currently in use in staging the disease can be used as biomarker tests operated colon cancer patients. Neutrophil, lymphocyte, monocyte, platelet, neutrophil/lymphocyte ratio (NLR), lymphocyte/monocyte ratio (LMR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte ratio (NMR), CRP, albumin, lymphocyte/CRP ratio, CRP/albumin ratio, and neutrophil/albumin ratio as systemic inflammatory biomarkers and prognostic nutritional index (PNI) were evaluated. Methods: This retrospective study included 592 patients. Patients with colon cancer in the cohort were divided into 2 subgroups: Tumor, nodes, metastases (TNM) stage 0, TNM stage 1, and TNM stage 2; early stage (n: 332) and TNM stage 3 and TNM stage 4; late stage (n: 260) colon cancer patients. Results: LDH (P <.001), NLR (P <.001), PLR (P <.05), CRP/albumin (P <.01), and neutrophil/albumin (P <.01) were significantly higher, while monocyte count (P <.05) and PNI (P <.01) were found to be significantly lower in late stage colon cancer patients than in early stage colon cancer patients. Moderate negative correlation was found between the PNI and the neutrophil/albumin ratio in late stage colon cancer patients (r: ?.568, P <.001). Conclusions: Our data suggest that high serum LDH, NLR, PLR, CRP/albumin, and neutrophil/albumin may be useful predictive markers for advanced stage in colon cancer. According to the receiver operating characteristic analysis results, CRP/albumin ratio can be used to discriminate early from late stage. Preoperative low monocyte count and PNI are associated with postoperative staging patients with colon cancer. © The Author(s) 2021. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 00031348 |
| العلاقة: | American Surgeon; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1177/0003134821995059Test; https://hdl.handle.net/20.500.12831/17877Test; 88; 1256; 1262; 2-s2.0-85118338461 |
| DOI: | 10.1177/0003134821995059 |
| الإتاحة: | https://doi.org/10.1177/0003134821995059Test https://doi.org/20.500.12831/17877Test https://hdl.handle.net/20.500.12831/17877Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.771A4673 |
| قاعدة البيانات: | BASE |
| تدمد: | 00031348 |
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| DOI: | 10.1177/0003134821995059 |