دورية أكاديمية
A novel shape memory plate osteosynthesis for noninvasive modulation of fixation stiffness in a rabbit tibia osteotomy model
| العنوان: | A novel shape memory plate osteosynthesis for noninvasive modulation of fixation stiffness in a rabbit tibia osteotomy model |
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| المؤلفون: | Müller, Christian W., Pfeifer, Ronny, Meier, Karen, Decker, Sebastian, Reifenrath, Janin, Gösling, Thomas, Wesling, Volker, Krettek, Christian, Hurschler, Christof, Krämer, Manuel |
| المصدر: | BioMed Research International 2015 (2015) |
| بيانات النشر: | Hindawi Publishing Corporation |
| سنة النشر: | 2015 |
| المجموعة: | Institutional Repository of Leibniz Universität Hannover |
| مصطلحات موضوعية: | nickel, titanium, biomaterial, titanium nickelide, adult, animal experiment, animal model, Article, body temperature, bone mass, bone plate, controlled study, fracture healing, in vitro study, male, nickel titanium shape memory alloy implant, nonhuman, osteotomy, plate fixation, rabbit model, radiography, randomized controlled trial, rigidity, shape memory effect, temperature measurement, tibia osteotomy, wound closure, Young modulus, animal, chemistry |
| الوصف: | Nickel-titanium shape memory alloy (NiTi-SMA) implants might allow modulating fracture healing, changing their stiffness through alteration of both elastic modulus and cross-sectional shape by employing the shape memory effect (SME). Hypotheses: a novel NiTi-SMA plate stabilizes tibia osteotomies in rabbits. After noninvasive electromagnetic induction heating the alloy exhibits the SME and the plate changes towards higher stiffness (inverse dynamization) resulting in increased fixation stiffness and equal or better bony healing. In 14 rabbits, 1.0 mm tibia osteotomies were fixed with our experimental plate. Animals were randomised for control or induction heating at three weeks postoperatively. Repetitive X-ray imaging and in vivo measurements of bending stiffness were performed. After sacrifice at 8 weeks, macroscopic evaluation, μCT, and post mortem bending tests of the tibiae were carried out. One death and one early implant dislocation occurred. Following electromagnetic induction heating, radiographic and macroscopic changes of the implant proved successful SME activation. All osteotomies healed. In the treatment group, bending stiffness increased over time. Differences between groups were not significant. In conclusion, we demonstrated successful healing of rabbit tibia osteotomies using our novel NiTi-SMA plate. We demonstrated shape-changing SME in-vivo through transcutaneous electromagnetic induction heating. Thus, future orthopaedic implants could be modified without additional surgery. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2314-6133 |
| العلاقة: | http://dx.doi.org/10.15488/4574Test; https://www.repo.uni-hannover.de/handle/123456789/4616Test |
| DOI: | 10.15488/4574 |
| الإتاحة: | https://doi.org/10.15488/4574Test https://doi.org/10.1155/2015/652940Test https://www.repo.uni-hannover.de/handle/123456789/4616Test |
| حقوق: | CC BY 3.0 Unported ; https://creativecommons.org/licenses/by/3.0Test/ ; frei zugänglich |
| رقم الانضمام: | edsbas.76B9A4A0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23146133 |
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| DOI: | 10.15488/4574 |