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Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients?

التفاصيل البيبلوغرافية
العنوان: Do cardiovascular risk factors confer the same risk for cardiovascular outcomes in rheumatoid arthritis patients as in non-rheumatoid arthritis patients?
المؤلفون: Gonzalez, A, Kremers, H Maradit, Crowson, C S, Ballman, K V, Roger, V L, Jacobsen, S J, O’Fallon, W M, Gabriel, S E
بيانات النشر: BMJ Publishing Group Ltd
سنة النشر: 2008
المجموعة: HighWire Press (Stanford University)
مصطلحات موضوعية: Extended reports
الوصف: Objective: To compare the frequency of traditional cardiovascular (CV) risk factors in rheumatoid arthritis (RA) compared to non-RA subjects, and examine their impact on the risk of developing selected CV events (myocardial infarction (MI), heart failure (HF) and CV death) in these two groups. Methods: We examined a population-based incidence cohort of subjects with RA (defined according to the 1987 American College of Rheumatology criteria), and an age- and sex-matched non-RA cohort. All subjects were followed longitudinally through their complete community medical records, until death, migration, or 1 January 2001. Clinical CV risk factors and outcomes were defined using validated criteria. The χ2 test was used to compare the frequency of each CV risk factor at baseline. Person-years methods were used to estimate the rate of occurrence of each CV risk factor during follow-up. Cox models were used to examine the influence of CV risk factors on the development of CV outcomes. Results: A total of 603 RA and 603 non-RA subjects (73% female; mean age 58 years) were followed for a mean of 15 and 17 years (total: 8842 and 10 101 person-years), respectively. At baseline, RA subjects were significantly more likely to be former or current smokers when compared to non-RA subjects (p<0.001). Male gender, smoking, and personal cardiac history had weaker associations with CV events among RA subjects, compared to non-RA subjects. There was no significant difference between RA and non-RA subjects in the risk imparted with respect to the other CV risk factors (ie, family cardiac history, hypertension, dyslipidaemia, body mass index, or diabetes mellitus). Conclusion: While some traditional CV risk factors imparted similar risk among RA compared with non-RA subjects, others (ie, male gender, smoking and personal cardiac history) imparted significantly less risk for the development of CV disease. These differences in the overall impact of traditional CV risk factors ...
نوع الوثيقة: text
وصف الملف: text/html
اللغة: English
العلاقة: http://ard.bmj.com/cgi/content/short/67/1/64Test; http://dx.doi.org/10.1136/ard.2006.059980Test
DOI: 10.1136/ard.2006.059980
الإتاحة: https://doi.org/10.1136/ard.2006.059980Test
http://ard.bmj.com/cgi/content/short/67/1/64Test
حقوق: Copyright (C) 2008, BMJ Publishing Group Ltd
رقم الانضمام: edsbas.76930DAF
قاعدة البيانات: BASE
الوصف
DOI:10.1136/ard.2006.059980