دورية أكاديمية
Electrical transport and dynamics of confined DNA through highly conductive 2D graphene nanochannels
| العنوان: | Electrical transport and dynamics of confined DNA through highly conductive 2D graphene nanochannels |
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| المؤلفون: | Cui, Y, Ying, C, Huang, X-Y, Ye, Q, Tian, J, Liu, Z |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2024 |
| المجموعة: | Nottingham Trent University's Institutional Repository (IRep) |
| الوصف: | Confining DNA in nanochannels is an important approach to studying its structure and transportation dynamics. Graphene nanochannels are particularly attractive for studying DNA confinement due to their atomic flatness, precise height control, and excellent mechanical strength. Here, using femtosecond laser etching and wetting transfer, we fabricate graphene nanochannels down to less than 4.3 nm in height, with the length-to-height ratios up to 103. These channels exhibit high stability, low noise, and self-cleaning ability during the long-term ionic current recording. We report a clear linear relationship between DNA length and the residence time in the channel and further utilize this relationship to differentiate DNA fragments based on their lengths, ranging widely from 200 bps to 48.5 kbps. The graphene nanochannel presented here provides a potential platform for label-free analyses and reveals fundamental insights into the conformational dynamics of DNA and proteins in confined space. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://irep.ntu.ac.uk/id/eprint/51222/1/1883122_Ying.pdfTest; CUI, Y., YING, C., HUANG, X.-Y., YE, Q., TIAN, J. and LIU, Z., 2024. Electrical transport and dynamics of confined DNA through highly conductive 2D graphene nanochannels. Nano Letters. ISSN 1530-6984 |
| DOI: | 10.1021/acs.nanolett.4c00403 |
| الإتاحة: | https://doi.org/10.1021/acs.nanolett.4c00403Test http://irep.ntu.ac.uk/id/eprint/51222Test/ https://irep.ntu.ac.uk/id/eprint/51222/1/1883122_Ying.pdfTest |
| رقم الانضمام: | edsbas.76577916 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.nanolett.4c00403 |
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