دورية أكاديمية
Correlation between left atrial spontaneous echocardiographic contrast and 5-year stroke/death in patients with non-valvular atrial fibrillation ; Corrélation entre la présence de contraste spontané dans l’oreillette gauche et le risque d’AVC ou de décès chez des patients en fibrillation atriale
| العنوان: | Correlation between left atrial spontaneous echocardiographic contrast and 5-year stroke/death in patients with non-valvular atrial fibrillation ; Corrélation entre la présence de contraste spontané dans l’oreillette gauche et le risque d’AVC ou de décès chez des patients en fibrillation atriale |
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| المؤلفون: | Soulat-Dufour, Laurie, Lang, Sylvie, Etienney, Arnaud, Ederhy, Stephane, Ancedy, Yann, Adavane, Saroumadi, Chauvet-Droit, Marion, Nhan, Pascal, Di Angelantonio, Emanuele, Boccara, Franck, Cohen, Ariel |
| المساهمون: | Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition CHU Pitié Salpêtrière (IHU ICAN), CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Saint-Antoine AP-HP, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU) |
| المصدر: | ISSN: 1875-2136. |
| بيانات النشر: | HAL CCSD Elsevier/French Society of Cardiology |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Atrial fibrillation, Thromboembolic risk, Echocardiography, CHA2DS2-VASc score, Reassessment, Fibrillation atriale, Risque thrombo-embolique, Échocardiographie, Reclassification, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background: Transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE) can be used to detect the presence of left atrial thrombus and left atrial spontaneous echocardiographic contrast (LASEC).Aim: To evaluate the prognostic value of TTE and TOE in predicting stroke and all-cause death at 5-year follow-up in patients with non-valvular atrial fibrillation (NVAF).Methods: This study included patients hospitalised with electrocardiography-diagnosed NVAF in Saint-Antoine University Hospital, Paris, between July 1998 and December 2011, who underwent TTE and TOE evaluation within 24hours of admission. Cox proportional-hazards models were used to identify predictors of the composite outcome (stroke or all-cause death).Results: During 5 years of follow-up, stroke/death occurred in 185/903 patients (20.5%). By multivariable analysis, independent predictors of stroke/death were CHA2DS2-VASc score (hazard ratio [HR] 1.35, 95% confidence interval [CI] 1.25-1.47; P<0.001), left atrial area>20 cm2 (HR 1.59, 95% CI 1.08-2.35; P=0.018), moderate LASEC (HR 1.72, 95% CI 1.13-2.62; P=0.012) and severe LASEC (HR 2.04, 95% CI 1.16-3.58; P=0.013). Independent protective predictors were dyslipidaemia (HR 0.60, 95% CI 0.43-0.83; P=0.002) and discharge prescription of anti-arrhythmics (HR 0.59, 95% CI 0.40-0.87; P=0.008). Adding LASEC to the CHA2DS2-VASc score modestly improved predictive accuracy and risk classification, with a C index of 0.71 vs. 0.69 (P=0.004).Conclusions: In this retrospective monocentric study, the presence of moderate/severe LASEC was an independent predictor of stroke/death at 5-year follow-up in patients with NVAF. The inclusion of LASEC in stroke risk scores could modestly improve risk stratification. ; ContexteL’échocardiographie transthoracique (ETT) et transoesophagienne (ETO) peuvent être utilisées pour détecter la présence d’un thrombus et le contraste spontané dans l’oreillette gauche (CS OG).ObjectifLe but de l’étude est d’évaluer la valeur pronostique ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32873521; hal-02965457; https://hal.sorbonne-universite.fr/hal-02965457Test; https://hal.sorbonne-universite.fr/hal-02965457/documentTest; https://hal.sorbonne-universite.fr/hal-02965457/file/S1875213620301236.pdfTest; PII: S1875-2136(20)30123-6; PUBMED: 32873521 |
| DOI: | 10.1016/j.acvd.2020.02.003 |
| الإتاحة: | https://doi.org/10.1016/j.acvd.2020.02.003Test https://hal.sorbonne-universite.fr/hal-02965457Test https://hal.sorbonne-universite.fr/hal-02965457/documentTest https://hal.sorbonne-universite.fr/hal-02965457/file/S1875213620301236.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.762681FC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.acvd.2020.02.003 |
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