دورية أكاديمية
Where do we stand after decades of studying human cytomegalovirus?
| العنوان: | Where do we stand after decades of studying human cytomegalovirus? |
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| المؤلفون: | Gugliesi Francesca, Coscia Alessandra, Griffante Gloria, Galitska Ganna, Pasquero Selina, Albano Camilla, Biolatti Matteo |
| المساهمون: | Gugliesi Francesca, Coscia Alessandra, Griffante Gloria, Galitska Ganna, Pasquero Selina, Albano Camilla, Biolatti Matteo |
| سنة النشر: | 2020 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | Antiviral therapy, Genetic variability, Human cytomegaloviru, Pathogenesi, Viral dissemination |
| الوصف: | Human cytomegalovirus (HCMV), a linear double-stranded DNA betaherpesvirus belonging to the family of Herpesviridae, is characterized by widespread seroprevalence, ranging between 56% and 94%, strictly dependent on the socioeconomic background of the country being considered. Typically, HCMV causes asymptomatic infection in the immunocompetent population, while in immunocompromised individuals or when transmitted vertically from the mother to the fetus it leads to systemic disease with severe complications and high mortality rate. Following primary infection, HCMV establishes a state of latency primarily in myeloid cells, from which it can be reactivated by various inflammatory stimuli. Several studies have shown that HCMV, despite being a DNA virus, is highly prone to genetic variability that strongly influences its replication and dissemination rates as well as cellular tropism. In this scenario, the few currently available drugs for the treatment of HCMV infections are characterized by high toxicity, poor oral bioavailability, and emerging resistance. Here, we review past and current literature that has greatly advanced our understanding of the biology and genetics of HCMV, stressing the urgent need for innovative and safe anti-HCMV therapies and effective vaccines to treat and prevent HCMV infections, particularly in vulnerable populations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32397070; info:eu-repo/semantics/altIdentifier/wos/WOS:000540222300066; volume:8; issue:5; firstpage:685; lastpage:714; numberofpages:30; journal:MICROORGANISMS; http://hdl.handle.net/2318/1740741Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85084373428; https://www.mdpi.com/2076-2607/8/5/685Test |
| DOI: | 10.3390/microorganisms8050685 |
| الإتاحة: | https://doi.org/10.3390/microorganisms8050685Test http://hdl.handle.net/2318/1740741Test https://www.mdpi.com/2076-2607/8/5/685Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.760709FD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/microorganisms8050685 |
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