دورية أكاديمية
Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer
| العنوان: | Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer |
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| المؤلفون: | Hanker, Lars, El-Balat, A., Drosos, Z., Kommoss, S., Karn, T., Holtrich, U., Gitas, G., Graeser-Mayer, M., Anglesio, M., Huntsman, D., Rody, A., Gevensleben, H., Hoellen, F. |
| المصدر: | http://lobid.org/resources/99370674181806441Test#!, 147(5):1421-1430. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Carcinoma, Ovarian Epithelial/mortality [MeSH], Female [MeSH], Aged, 80 and over [MeSH], Aged [MeSH], Original Article – Cancer Research, Adult [MeSH], Ovarian cancer, Humans [MeSH], Progression-Free Survival [MeSH], Middle Aged [MeSH], Prognosis, Ovarian Epithelial/metabolism [MeSH], Biomarkers, Tumor/metabolism [MeSH], Prognosis [MeSH], Young Adult [MeSH], SPHK1, Immunohistochemistry/methods [MeSH], Phosphotransferases (Alcohol Group Acceptor)/metabolism [MeSH] |
| الوصف: | Purpose!#!Sphingosine-kinase-1 (SPHK1) is a key enzyme of sphingolipid metabolism which is involved in ovarian cancer pathogenesis, progression and mechanisms of drug resistance. It is overexpressed in a variety of cancer subtypes. We investigated SPHK1 expression as a prognostic factor in epithelial ovarian cancer patients.!##!Methods!#!Expression analysis of SPHK1 was performed on formalin-fixed paraffin-embedded tissue from 1005 ovarian cancer patients with different histological subtypes using immunohistochemistry. Staining intensity of positive tumor cells was assessed semi-quantitatively, and results were correlated with clinicopathological characteristics and survival.!##!Results!#!In our ovarian cancer collective, high levels of SPHK1 expression correlated significantly with complete surgical tumor resection (p = 0.002) and lower FIGO stage (p = 0.04). Progression-free and overall survival were further significantly longer in patients with high-grade serous ovarian cancer and overexpression of SPHK1 (p = 0.002 and p = 0.006, respectively).!##!Conclusion!#!Our data identify high levels of SPHK1 expression as a potential favorable prognostic marker in ovarian cancer patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6449928Test; https://doi.org/10.1007/s00432-021-03558-xTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021516Test/ |
| DOI: | 10.1007/s00432-021-03558-x |
| الإتاحة: | https://doi.org/10.1007/s00432-021-03558-xTest https://repository.publisso.de/resource/frl:6449928Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8021516Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.75DD94 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00432-021-03558-x |
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