دورية أكاديمية
Health effects of the New Nordic Renal Diet in patients with stage 3 and 4 chronic kidney disease, compared to habitual diet:A randomized trial
| العنوان: | Health effects of the New Nordic Renal Diet in patients with stage 3 and 4 chronic kidney disease, compared to habitual diet:A randomized trial |
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| المؤلفون: | Misella Hansen, Nikita, Kamper, Anne-Lise, Rix, Marianne, Feldt-Rasmussen, Bo, Leipziger, Jens, Sørensen, Mads Vaarby, Berg, Peder, Astrup, Arne, Salomo, Louise |
| المصدر: | Misella Hansen , N , Kamper , A-L , Rix , M , Feldt-Rasmussen , B , Leipziger , J , Sørensen , M V , Berg , P , Astrup , A & Salomo , L 2023 , ' Health effects of the New Nordic Renal Diet in patients with stage 3 and 4 chronic kidney disease, compared to habitual diet : A randomized trial ' , American Journal of Clinical Nutrition . https://doi.org/10.1016/j.ajcnut.2023.08.008Test , https://doi.org/10.1016/j.ajcnut.2023.08.008Test |
| سنة النشر: | 2023 |
| المجموعة: | Aarhus University: Research |
| الوصف: | BACKGROUND: Chronic kidney disease (CKD) leads to an accumulation of waste products and causes adverse cardiometabolic effects. OBJECTIVE: We investigated the health effects of the New Nordic Renal Diet (NNRD), a novel meal pattern reduced in phosphorus, protein, and sodium. METHODS: A 26-week randomized trial compared the NNRD with a habitual diet. The NNRD group received weekly home deliveries of food and recipes. Monthly study visits included fasting blood samples, 24h urine samples, blood pressure and anthropometric measurements. Intention-to-treat analysis used linear mixed-effects models. RESULTS: Sixty patients, mean estimated glomerular filtration rate (eGFR) 34 ml/min/1.73 m2, BMI 25-27 kg/m2 were included, 58 completed. Metabolic syndrome was present in 53% (NNRD group), and 57% (control group). The NNRD group (n=30) reduced their 24h urine phosphorus excretion by 19% [-153 mg (95% CI; -210, -95)], control group (n=30) (no change), between-group difference -171 mg (95% CI; -233, -109, p<0.001). Proteinuria was reduced by 39% in the NNRD group [-0.33 g/d (95% CI; -0.47, -0.18)], control group (no change), between-group difference -0.34 g/d (95% CI; -0.52, -0.17, p<0.001). Plasma urea was reduced by -1.5 mmol/L in the NNRD group (95% CI; -2.1, -0.9), control group (no change), between-group difference -1.4 mmol/L (95% CI; -2.0, -0.7, p<0.001). Systolic blood pressure fell by -5.2 mmHg in the NNRD group (95% CI; -8.4, -2.1), control group (no change), between-group difference -3.9 mmHg (95% CI; -7.6, -0.2, p=0.04). The NNRD group lost -1.7 kg (95% CI; -2.6, -0.8), control group (no change), between-group difference -2.0 kg (95% CI; -3.0, -1.0, p<0.001). There were no effects on eGFR during the 26-week intervention. CONCLUSION: NNRD in moderate CKD reduces phosphorus excretion, proteinuria, systolic blood pressure, and weight, mainly by reducing abdominal fat. CLINICAL TRIAL REGISTRY: NCT04579315. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://pure.au.dk/portal/da/publications/health-effects-of-the-new-nordic-renal-diet-in-patients-with-stage-3-and-4-chronic-kidney-disease-compared-to-habitual-dietTest(5e2f1854-fcd6-4f89-9e51-50c6803abd49).html |
| DOI: | 10.1016/j.ajcnut.2023.08.008 |
| الإتاحة: | https://doi.org/10.1016/j.ajcnut.2023.08.008Test https://pure.au.dk/portal/da/publications/health-effects-of-the-new-nordic-renal-diet-in-patients-with-stage-3-and-4-chronic-kidney-disease-compared-to-habitual-dietTest(5e2f1854-fcd6-4f89-9e51-50c6803abd49).html |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.75D7ECA4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ajcnut.2023.08.008 |
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