دورية أكاديمية
In vitro biological activity of liposomal-containing antimony trioxide ; Actividad biológica in vitro de liposomas que contienen trióxido de antimônio ; Atividade biológica in vitro de lipossomas contendo trióxido de antimônio
| العنوان: | In vitro biological activity of liposomal-containing antimony trioxide ; Actividad biológica in vitro de liposomas que contienen trióxido de antimônio ; Atividade biológica in vitro de lipossomas contendo trióxido de antimônio |
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| المؤلفون: | Viana, Altevir Rossato, Bottega, Angelita, Serafin, Marissa Bolson, Salles, Bruno, Horner, Rosmari, Krause, Alexandre, Maria Fontanari Krause, Luciana, Mortari, Sergio Roberto |
| المصدر: | Research, Society and Development; Vol. 10 No. 11; e391101119755 ; Research, Society and Development; Vol. 10 Núm. 11; e391101119755 ; Research, Society and Development; v. 10 n. 11; e391101119755 ; 2525-3409 |
| بيانات النشر: | Research, Society and Development |
| سنة النشر: | 2021 |
| المجموعة: | Research, Society and Development (E-Journal) |
| مصطلحات موضوعية: | Bacteria, Cáncer, Linaje celular, Nanotecnología, Reposicionamiento, Cancer, Linhagem Celular, Nanotecnologia, Reposicionamento, Cell Line, Nanotechnology, Repositioning |
| الوصف: | Antimonials are used as chemotherapy for leishmaniasis, but have limited results due to their toxicity and broad resistance already acquired by the parasites. Nanotechnology offers an alternative to reduce these effects through the use of biocompatible nanocarriers, which can be vectorized to the target site. In addition, the redirection of molecules, already developed for the treatment of other pathologies, has the advantage of being already approved for therapy by regulatory agencies. The present study addresses the production of liposomal vesicles containing antimony trioxide (LC Sb2O3), as well as the evaluation of activity against tumor and bacterial cells. We produce liposomes in order of nanometric size, polydispersity index (PDI <0.3), pH value close to physiological (7.2), and zeta potential (anionic). Cytotoxicity was evaluated in 24 and 72 hours, in the HepG2, T98G, and U87MG tumor cell lines, by the method (3-4.5 dimethylthiazole-2.5 diphenyltetrazolium bromide) (MTT). The minimum inhibitory concentration (MIC) was tested on three bacterial strains (American Type Culture Collection – ATCC-Escherichia coli ATCC 35218, Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212) and mandatory (Staphylococcus aureus and Klebsiella pneumoniae). The liposomes were more cytotoxic than Sb2O3 in the free form, for all tested cell lines. This effect was stronger after 72 hours incubation. Antimony trioxide in both free and liposomal forms showed low antibacterial activity. Based on our results, we suggest that liposomes containing antimony trioxide have the potential for the repositioning of drugs addressing anticancer therapy. ; Los antimoniales se utilizan como quimioterapia para la leishmaniasis, pero tienen resultados limitados debido a su toxicidad y amplia resistencia ya adquirida por los parásitos. La nanotecnología ofrece una alternativa para reducir estos efectos mediante el uso de nanoportadores biocompatibles, que pueden ser vectorizados. Además, el redireccionamiento de moléculas, ya ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://rsdjournal.org/index.php/rsd/article/view/19755/17649Test; https://rsdjournal.org/index.php/rsd/article/view/19755Test |
| DOI: | 10.33448/rsd-v10i11.19755 |
| الإتاحة: | https://doi.org/10.33448/rsd-v10i11.19755Test https://rsdjournal.org/index.php/rsd/article/view/19755Test |
| حقوق: | Copyright (c) 2021 Altevir Rossato Viana; Angelita Bottega; Marissa Bolson Serafin; Bruno Salles; Rosmari Horner; Alexandre Krause; Luciana Maria Fontanari Krause; Sergio Roberto Mortari ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.75B6E52F |
| قاعدة البيانات: | BASE |
| DOI: | 10.33448/rsd-v10i11.19755 |
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