دورية أكاديمية
EEG-fMRI in the presurgical evaluation of temporal lobe epilepsy
| العنوان: | EEG-fMRI in the presurgical evaluation of temporal lobe epilepsy |
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| المؤلفون: | Coan, Ana C, Chaudhary, Umair J, Frédéric Grouiller, Campos, Brunno M, Perani, Suejen, De Ciantis, Alessio, Vulliemoz, Serge, Diehl, Beate, Beltramini, Guilherme C, Carmichael, David W, Thornton, Rachel C, Covolan, Roberto J, Cendes, Fernando, Lemieux, Louis |
| المصدر: | Coan , A C , Chaudhary , U J , Frédéric Grouiller , Campos , B M , Perani , S , De Ciantis , A , Vulliemoz , S , Diehl , B , Beltramini , G C , Carmichael , D W , Thornton , R C , Covolan , R J , Cendes , F & Lemieux , L 2016 , ' EEG-fMRI in the presurgical evaluation of temporal lobe epilepsy ' , Journal of Neurology, Neurosurgery and Psychiatry , vol. 87 , no. 6 , pp. 642-9 . https://doi.org/10.1136/jnnp-2015-310401Test |
| سنة النشر: | 2016 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | Adolescent, Adult, Brain Mapping, Child, Drug Resistant Epilepsy/diagnosis, Electroencephalography, Epilepsy, Temporal Lobe/diagnosis, Female, Follow-Up Studies, Hemodynamics/physiology, Humans, Image Enhancement, Magnetic Resonance Imaging, Male, Middle Aged, Outcome Assessment (Health Care), Oxygen/blood, Predictive Value of Tests, Preoperative Care, Retrospective Studies, Temporal Lobe/blood supply, Video Recording, Young Adult |
| الوصف: | OBJECTIVE: Drug-resistant temporal lobe epilepsy (TLE) often requires thorough investigation to define the epileptogenic zone for surgical treatment. We used simultaneous interictal scalp EEG-fMRI to evaluate its value for predicting long-term postsurgical outcome. METHODS: 30 patients undergoing presurgical evaluation and proceeding to temporal lobe (TL) resection were studied. Interictal epileptiform discharges (IEDs) were identified on intra-MRI EEG and used to build a model of haemodynamic changes. In addition, topographic electroencephalographic correlation maps were calculated between the average IED during video-EEG and intra-MRI EEG, and used as a condition. This allowed the analysis of all data irrespective of the presence of IED on intra-MRI EEG. Mean follow-up after surgery was 46 months. International League Against Epilepsy (ILAE) outcomes 1 and 2 were considered good, and 3-6 poor, surgical outcome. Haemodynamic maps were classified according to the presence (Concordant) or absence (Discordant) of Blood Oxygen Level-Dependent (BOLD) change in the TL overlapping with the surgical resection. RESULTS: The proportion of patients with good surgical outcome was significantly higher (13/16; 81%) in the Concordant than in the Discordant group (3/14; 21%) (χ(2) test, Yates correction, p=0.003) and multivariate analysis showed that Concordant BOLD maps were independently related to good surgical outcome (p=0.007). Sensitivity and specificity of EEG-fMRI results to identify patients with good surgical outcome were 81% and 79%, respectively, and positive and negative predictive values were 81% and 79%, respectively. INTERPRETATION: The presence of significant BOLD changes in the area of resection on interictal EEG-fMRI in patients with TLE retrospectively confirmed the epileptogenic zone. Surgical resection including regions of haemodynamic changes in the TL may lead to better postoperative outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/jnnp-2015-310401 |
| الإتاحة: | https://doi.org/10.1136/jnnp-2015-310401Test https://kclpure.kcl.ac.uk/portal/en/publications/84846eff-d25b-4cb1-b206-8b8b614b33c4Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.75B26BCA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/jnnp-2015-310401 |
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