دورية أكاديمية
أعرض في EDS

Impaired Blood Rheology and Elevated Remnant-like Lipoprotein Particle Cholesterol in Hypercholesterolaemic Subjects

التفاصيل البيبلوغرافية
العنوان: Impaired Blood Rheology and Elevated Remnant-like Lipoprotein Particle Cholesterol in Hypercholesterolaemic Subjects
المؤلفون: Nara, M, Sumino, H, Machida, T, Amagai, H, Nakajima, K, Murakami, M
المصدر: Journal of International Medical Research ; volume 37, issue 2, page 308-317 ; ISSN 0300-0605 1473-2300
بيانات النشر: SAGE Publications
سنة النشر: 2009
الوصف: Blood rheology, fasting serum concentrations of remnant-like lipoprotein particle cholesterol (RLP-C) and concentrations of other lipids were compared in 23 hypercholesterolaemic and 69 normocholesterolaemic subjects, and the relationship between red blood cell (RBC) deformability and RLP-C concentrations were studied in a different set of six hypercholesterolaemic and six normocholesterolaemic subjects. Passage time of whole blood and concentrations of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and RLP-C were significantly higher in hypercholesterolaemic than in normocholesterolaemic subjects. Passage time of whole blood correlated positively with TC, TG, LDL-C and RLP-C and negatively with high-density lipoprotein cholesterol. Furthermore, the passage time of 10% haematocrit-adjusted RBCs in phosphate-buffered saline, which reflects RBC deformability, correlated positively with the passage time of whole blood and RLP-C. Thus, hypercholesterolaemic subjects had impaired blood rheology and elevated RLP-C concentrations, which may be associated with the pathophysiology of atherosclerosis in hypercholesterolaemic subjects. Impaired RBC deformability may contribute to impaired blood rheology associated with elevated RLP-C in hypercholesterolaemic subjects.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1177/147323000903700204
الإتاحة: https://doi.org/10.1177/147323000903700204Test
حقوق: http://journals.sagepub.com/page/policies/text-and-data-mining-licenseTest
رقم الانضمام: edsbas.75AE438E
قاعدة البيانات: BASE
الوصف
DOI:10.1177/147323000903700204