دورية أكاديمية
Prediagnostic Levels of Copper and Zinc and Breast Cancer Risk in the ORDET Cohort
| العنوان: | Prediagnostic Levels of Copper and Zinc and Breast Cancer Risk in the ORDET Cohort |
|---|---|
| المؤلفون: | Pala V., Agnoli C., Cavalleri A., Rinaldi S., Orlandi R., Segrado F., Venturelli E., Vinceti M., Krogh V., Sieri S. |
| المساهمون: | Pala, V., Agnoli, C., Cavalleri, A., Rinaldi, S., Orlandi, R., Segrado, F., Venturelli, E., Vinceti, M., Krogh, V., Sieri, S. |
| سنة النشر: | 2022 |
| المجموعة: | Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| مصطلحات موضوعية: | Case-Control Studie, Copper, Female, Human, Prospective Studie, Breast Neoplasm, Zinc |
| الوصف: | Background: Case–control studies show that copper (Cu) is high and zinc (Zn) low in blood and urine of women with breast cancer compared with controls. Methods: To assess whether prediagnostic Cu and Zn are associated with breast cancer risk, OR of breast cancer according to Cu, Zn, and Cu/Zn ratio in plasma and urine was estimated in a nested case–control study within the ORDET cohort, using conditional logistic regression adjusted for multiple variables: First 496 breast cancer cases and matched controls, diagnosed ≥2 years after recruitment (to eliminate reverse causation) were analyzed. Then all eligible cases/controls were analyzed with stratification into years from recruitment to diagnosis. Results: For women diagnosed ≥2 years, compared with lowest tertiles, breast cancer risk was higher in the highest tertile of plasma Cu/Zn ratio (OR, 1.75; 95% CI, 1.21–2.54) and the highest tertile of both plasma and urine Cu/Zn ratio (OR, 2.37; 95% CI, 1.32–4.25). Risk did not vary with ER/PR/HER2 status. For women diagnosed <2 years, high Cu/Zn ratio was strongly associated with breast cancer risk. Conclusions: Our prospective findings suggest that increased Cu/Zn ratio in plasma and urine may be both an early marker of, and a risk factor for, breast cancer development. Further studies are justified to confirm or otherwise our results and to investigate mechanisms. Impact: Our finding that prediagnostic Cu/Zn ratio is a strong risk factor for breast cancer development deserves further investigation and, if confirmed, might open the way to interventions to reduce breast cancer risk in women with disrupted Cu/Zn homeostasis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35255128; info:eu-repo/semantics/altIdentifier/wos/WOS:000807808800001; volume:31; issue:6; firstpage:1209; lastpage:1215; journal:CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION; http://hdl.handle.net/11380/1278977Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85131225530 |
| DOI: | 10.1158/1055-9965.EPI-21-1252 |
| الإتاحة: | https://doi.org/10.1158/1055-9965.EPI-21-1252Test http://hdl.handle.net/11380/1278977Test |
| رقم الانضمام: | edsbas.75978E07 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1158/1055-9965.EPI-21-1252 |
|---|