دورية أكاديمية
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma
| العنوان: | Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma |
|---|---|
| المؤلفون: | Went, M, Sud, A, Forsti, A, Halvarsson, B-M, Weinhold, N, Kimber, S, van Duin, M, Thorleifsson, G, Holroydl, A, Johnson, DC, Li, N, Orlando, G, Law, PJ, Ali, M, Chen, B, Mitchell, JS, Gudbjartsson, DF, Kuiper, R, Stephens, OW, Bertsch, U, Broderick, P, Campo, C, Bandapalli, OR, Einsele, H, Gregory, WA, Gullberg, U, Hillengass, J, Hoffmann, P, Jackson, GH, Joeckel, K-H, Johnsson, E, Kristinsson, SY, Mellqvist, U-H, Nahi, H, Easton, D, Pharoah, P, Dunning, A, Peto, J, Canzian, F, Swerdlow, A, Eeles, RA, Kote-Jarai, Z, Muir, K, Pashayan, N, Nickel, J, Noethen, MM, Rafnar, T, Ross, FM, Filho, MIDS, Thomsen, H, Turesson, I, Vangsted, A, Andersen, NF, Waage, A, Walker, BA, Wihlborg, A-K, Broyl, A, Davies, FE, Thorsteinsdottir, U, Langer, C, Hansson, M, Goldschmidt, H, Kaiser, M, Sonneveld, P, Stefansson, K, Morgans, GJ, Hemminki, K, Nilsson, B, Houlston, RS, The PRACTICAL consortium, . |
| المصدر: | Nature Communications , 9 , Article 3707. (2018) |
| بيانات النشر: | NATURE PUBLISHING GROUP |
| سنة النشر: | 2018 |
| المجموعة: | University College London: UCL Discovery |
| الوصف: | Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous GWAS and a replication series, totalling 9974 MM cases and 247,556 controls of European ancestry. Collectively, these data provide evidence for six new MM risk loci, bringing the total number to 23. Integration of information from gene expression, epigenetic profiling and in situ Hi-C data for the 23 risk loci implicate disruption of developmental transcriptional regulators as a basis of MM susceptibility, compatible with altered B-cell differentiation as a key mechanism. Dysregulation of autophagy/apoptosis and cell cycle signalling feature as recurrently perturbed pathways. Our findings provide further insight into the biological basis of MM. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10057250/1/Identification%20of%20multiple%20risk%20loci%20and%20regulatory%20mechanisms%20influencing%20susceptibility%20to%20multiple%20myeloma.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10057250Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10057250/1/Identification%20of%20multiple%20risk%20loci%20and%20regulatory%20mechanisms%20influencing%20susceptibility%20to%20multiple%20myeloma.pdfTest https://discovery.ucl.ac.uk/id/eprint/10057250Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.75192049 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |