التفاصيل البيبلوغرافية
| العنوان: |
Derepression of stress genes in cbf11Δ cells is associated with H3K9 hyperacetylation in their promoters (the second replicate) but not with altered total cellular acetyl-CoA levels. |
| المؤلفون: |
Jarmila Princová (14375178), Clàudia Salat-Canela (14375181), Petr Daněk (14375184), Anna Marešová (14375187), Laura de Cubas (13037335), Jürg Bähler (7135), José Ayté (51457), Elena Hidalgo (51458), Martin Převorovský (209870) |
| سنة النشر: |
2023 |
| مصطلحات موضوعية: |
Microbiology, Cell Biology, Genetics, Molecular Biology, Developmental Biology, Mental Health, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, main pathway responding, corresponding gene promoters, mst1 histone acetyltransferases, schizosaccharomyces pombe <, pap1 transcription factor, show increased expression, localized chromatin hyperacetylation, div >< p, response gene expression, increased cellular resistance, atf1 transcription factor, conserved sty1 stress, gene expression, increased stress, increased acetylation, histone h3, response mechanisms, response genes, regulating transcription, mga2 <, cut6 < |
| الوصف: |
(A) Average gene profiles of total H3 (bottom panels) and acetylated H3K9 (top panels) occupancy at stress-gene regions in WT and cbf11Δ cells, respectively. Genes upregulated as part of the core environmental stress response (CESR-UP, [ 9 ]) have been divided into those showing upregulation in untreated cbf11Δ cells (blue; n = 94, [ 15 ]) and the rest (red; n = 441). Average profile of all fission yeast genes is also shown for comparison (black; n = 6952). The curves represent mean RPM (reads per million mapped reads) values ± SEM. The promoter region is shaded. TSS—transcription start site. (B) Total cellular acetyl-CoA levels in WT, ppc1-537 , cbf11Δ and Pcut6MUT cell extracts were determined by LC-MS. Mean and SD values of four independent replicates for ppc1-537 and five independent replicates for all other strains tested are shown. Two-sided Mann-Whitney U test was used to determine statistical significance. (TIF) |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/figure/Derepression_of_stress_genes_in_i_cbf11_i_cells_is_associated_with_H3K9_hyperacetylation_in_their_promoters_the_second_replicate_but_not_with_altered_total_cellular_acetyl-CoA_levels_/21861099Test |
| DOI: |
10.1371/journal.pgen.1010582.s004 |
| الإتاحة: |
https://doi.org/10.1371/journal.pgen.1010582.s004Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.74C23AF4 |
| قاعدة البيانات: |
BASE |
