دورية أكاديمية
Assessment of postprandial triglycerides in clinical practice: Validation in a general population and coronary heart disease patients.
| العنوان: | Assessment of postprandial triglycerides in clinical practice: Validation in a general population and coronary heart disease patients. |
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| المؤلفون: | Perez-Martinez, Pablo, Alcala-Diaz, Juan F, Kabagambe, Edmon K, Garcia-Rios, Antonio, Tsai, Michael Y, Delgado-Lista, Javier, Kolovou, Genovefa, Straka, Robert J, Gomez-Delgado, Francisco, Hopkins, Paul N, Marin, Carmen, Borecki, Ingrid, Yubero-Serrano, Elena M, Hixson, James E, Camargo, Antonio, Province, Michael A, Lopez-Moreno, Javier, Rodriguez-Cantalejo, Fernando, Tinahones, Francisco J, Mikhailidis, Dimitri P, Perez-Jimenez, Francisco, Arnett, Donna K, Ordovas, Jose M, Lopez-Miranda, Jose |
| سنة النشر: | 2016 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | CORDIOPREV study, Coronary heart disease, GOLDN study, Oral-fat tolerance test, Postprandial lipemia, Triglycerides, Adult, Age Factors, Aged, Coronary Artery Disease, Dietary Fats, Female, Humans, Hyperlipidemias, Logistic Models, Male, Middle Aged, Odds Ratio, Postprandial Period, Prevalence |
| الوصف: | Previous studies have suggested that for clinical purposes, subjects with fasting triglycerides (TGs) between 89-180 mg/dl (1-2 mmol/l) would benefit from postprandial TGs testing. To determine the postprandial TG response in 2 independent studies and validate who should benefit diagnostically from an oral-fat tolerance test (OFTT) in clinical practice. A population of 1002 patients with coronary heart disease (CHD) from the CORDIOPREV clinical trial and 1115 white US subjects from the GOLDN study underwent OFTTs. Subjects were classified into 3 groups according to fasting cut points of TGs to predict the usefulness of OFTT: (1) TG 180 mg/dl (>2 mmol/l). Postprandial TG concentration at any point > 220 mg/dl (>2.5 mmol/l) has been pre-established as an undesirable postprandial response. Of the total, 49% patients with CHD and 42% from the general population showed an undesirable response after the OFTT. The prevalence of undesirable postprandial TG in the CORDIOPREV clinical trial was 12.8, 50.3, and 89.7%, in group 1, 2, and 3, respectively (P These two studies validate the predictive values reported in a previous consensus. Moreover, the findings of the CORDIOPREV and GOLDN studies show that an OFTT is useful to identify postprandial hyperlipidemia in subjects with fasting TG between 1-2 mmol/l (89-180 mg/dL), because approximately half of them have hidden postprandial hyperlipidemia, which may influence treatment. An OFTT does not provide additional information regarding postprandial hyperlipidemia in subjects with low TG (2 mmol/l, >180 mg/dl). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1933-2874 |
| العلاقة: | http://hdl.handle.net/10668/10481Test; PMC7025632; https://europepmc.org/articles/pmc7025632?pdf=renderTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025632/pdfTest |
| DOI: | 10.1016/j.jacl.2016.05.009 |
| الإتاحة: | https://doi.org/10.1016/j.jacl.2016.05.009Test http://hdl.handle.net/10668/10481Test https://europepmc.org/articles/pmc7025632?pdf=renderTest https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025632/pdfTest |
| حقوق: | open access |
| رقم الانضمام: | edsbas.74B8CC70 |
| قاعدة البيانات: | BASE |
| تدمد: | 19332874 |
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| DOI: | 10.1016/j.jacl.2016.05.009 |