التفاصيل البيبلوغرافية
| العنوان: |
PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis |
| المؤلفون: |
Zhang, Yuhua, Quick, Corbin, Yu, Ketian, Barbeira, Alvaro, Luca, Francesca, Pique-Regi, Roger, Kyung Im, Hae, Wen, Xiaoquan |
| المصدر: |
Genome Biology ; volume 21, issue 1 ; ISSN 1474-760X |
| بيانات النشر: |
Springer Science and Business Media LLC |
| سنة النشر: |
2020 |
| الوصف: |
We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits. PTWAS applies the established principles from instrumental variables analysis and takes advantage of probabilistic eQTL annotations to delineate and tackle the unique challenges arising in TWAS. PTWAS not only confers higher power than the existing methods but also provides novel functionalities to evaluate the causal assumptions and estimate tissue- or cell-type-specific gene-to-trait effects. We illustrate the power of PTWAS by analyzing the eQTL data across 49 tissues from GTEx (v8) and GWAS summary statistics from 114 complex traits. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1186/s13059-020-02026-y |
| DOI: |
10.1186/s13059-020-02026-y.pdf |
| DOI: |
10.1186/s13059-020-02026-y/fulltext.html |
| الإتاحة: |
https://doi.org/10.1186/s13059-020-02026-yTest |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: |
edsbas.748493C7 |
| قاعدة البيانات: |
BASE |
