Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity

التفاصيل البيبلوغرافية
العنوان:	Discovery of Pyrazolo[1,5-a]pyrazin-4-ones as Potent and Brain Penetrant GluN2A-Selective Positive Allosteric Modulators Reducing AMPA Receptor Binding Activity
المؤلفون:	Sakurai, Fumie, Yukawa, Takafumi, Kina, Asato, Murakami, Masataka, Takami, Kazuaki, Morimoto, Sachie, Seto, Masaki, Kamata, Makoto, Yamashita, Tohru, Nakashima, Kosuke, Narita, Naohiro, Bettini, Ezio, Ugolini, Annarosa, Corsi, Mauro, Hasui, Tomoaki
المصدر:	Bioorganic & Medicinal Chemistry ; volume 56, page 116576 ; ISSN 0968-0896
بيانات النشر:	Elsevier BV
سنة النشر:	2022
المجموعة:	ScienceDirect (Elsevier - Open Access Articles via Crossref)
مصطلحات موضوعية:	Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Biology, Molecular Medicine, Biochemistry
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
DOI:	10.1016/j.bmc.2021.116576
الإتاحة:	https://doi.org/10.1016/j.bmc.2021.116576Test https://api.elsevier.com/content/article/PII:S0968089621005848?httpAccept=text/xmlTest https://api.elsevier.com/content/article/PII:S0968089621005848?httpAccept=text/plainTest
حقوق:	https://www.elsevier.com/tdm/userlicense/1.0Test/ ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/
رقم الانضمام:	edsbas.7467A085
قاعدة البيانات:	BASE

الوصف
DOI:	10.1016/j.bmc.2021.116576