دورية أكاديمية
No relation between the severity of corneal nerve, epithelial, and keratocyte cell morphology with measures of dry eye disease in type 1 diabetes
| العنوان: | No relation between the severity of corneal nerve, epithelial, and keratocyte cell morphology with measures of dry eye disease in type 1 diabetes |
|---|---|
| المؤلفون: | Ferdousi, Maryam, Petropoulos, Ioannis, Kalteniece, Alise, Azmi, Shazli, Ponirakis, Georgios, Efron, Nathan, Soran, Handrean, Malik, Rayaz |
| المصدر: | Investigative Ophthalmology and Visual Science |
| بيانات النشر: | Association for Research in Vision and Ophthalmology Inc. |
| سنة النشر: | 2018 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| الوصف: | Purpose: Patients with diabetes have a propensity to develop dry eye symptoms (DES), with reduced tear secretion and corneal sensitivity. The underlying pathologic basis of DES was explored in patients with Type 1 diabetes. Methods: Forty-two patients with Type 1 diabetes mellitus (T1DM) (age: 49.21 ± 2.53 years, duration of diabetes: 29.98 ± 2.64 years) and 25 control subjects (age: 48.70 ± 2.84 years) underwent assessment of DES using a validated dry eye questionnaire, and tear stability and tear production were assessed using tear breakup time (TBUT) and Schirmer's test, respectively. Corneal confocal microscopy was undertaken to quantify corneal nerve fiber density (CNFD), branch density (CNBD), fiber length (CNFL), keratocyte density (KD), and corneal epithelial basal cell (CEBC) density and area. Results: The prevalence of DES was significantly higher (P = 0.03), and TBUT (P = 0.006), corneal sensation (P < 0.0001), CNFD (P = 0.001), CNBD (P = 0.001), CNFL (P = 0.003), and KD (P = 0.04) were significantly lower in patients with T1DM compared to control subjects. However, these measures did not differ significantly between T1DM patients with and without dry eye. There was no correlation between DES and TBUT or corneal nerve keratocyte and CEBC morphology. Conclusions: DES and TBUT are significantly increased in patients with T1DM, but are not related to corneal nerve, basal epithelial, or keratocyte cell morphology. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/123688/1/i1552-5783-59-13-5525.pdfTest; Ferdousi, Maryam, Petropoulos, Ioannis, Kalteniece, Alise, Azmi, Shazli, Ponirakis, Georgios, Efron, Nathan, Soran, Handrean, & Malik, Rayaz (2018) No relation between the severity of corneal nerve, epithelial, and keratocyte cell morphology with measures of dry eye disease in type 1 diabetes. Investigative Ophthalmology and Visual Science, 59(13), pp. 5525-5530.; https://eprints.qut.edu.au/123688Test/; Faculty of Health; Institute of Health and Biomedical Innovation |
| الإتاحة: | https://doi.org/10.1167/iovs.18-25321Test https://eprints.qut.edu.au/123688Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by-nc-nd/2.5Test/ ; Consult author(s) regarding copyright matters ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.74349362 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |