دورية أكاديمية
In utero treatment with monoclonal antibody to IL-2 receptor {beta}-chain completely abrogates development of Thy-1+ dendritic epidermal cells
| العنوان: | In utero treatment with monoclonal antibody to IL-2 receptor {beta}-chain completely abrogates development of Thy-1+ dendritic epidermal cells |
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| المؤلفون: | Tanaka, Toshiyuki, Takeuchi, Yumiko, Shiohara, Tetsuo, Kitamura, Fujiko, Nagasaka, Yasuhiko, Hamamura, Keisuke, Yagita, Hideo, Miyasaka, Masayuki |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1992 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Articles |
| الوصف: | lnterleukin-2 (IL-2), a crucial growth factor for mature T lymphocytes, Is produced in fetal thymus under developmental control, although its biological significance remains unclear. We found that the two distinct subunits of the IL-2 receptor, I.e. the a-chain (IL-2Rα) and the β-chaln (IL-2Rβ), were expressed In an almost mutually exclusive fashion throughout fetal thymus ontogeny, and that the blockade of IL-2Rβ, a signal transducing component of IL-2R, by administering a neutralizing mAb to IL-2Rβ resulted in the complete and selective disappearance of Thy-1+ skin dendritic epidermal cells. Development of any other T cell subsets was uncompromised. This indicates that IL-2 plays a crucial role in the development of fetal V γ 5+ cells and their descendants. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://intimm.oxfordjournals.org/cgi/content/short/4/4/487Test; http://dx.doi.org/10.1093/intimm/4.4.487Test |
| DOI: | 10.1093/intimm/4.4.487 |
| الإتاحة: | https://doi.org/10.1093/intimm/4.4.487Test http://intimm.oxfordjournals.org/cgi/content/short/4/4/487Test |
| حقوق: | Copyright (C) 1992, The Japanese Society for Immunology |
| رقم الانضمام: | edsbas.741CD3D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/intimm/4.4.487 |
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