دورية أكاديمية
Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease
| العنوان: | Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease |
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| المؤلفون: | Chiesa P. A., Cavedo E., Vergallo A., Lista S., Potier M. -C., Habert M. -O., Dubois B., Thiebaut de Schotten M., Hampel H., Bakardjian H., Benali H., Bertin H., Bonheur J., Boukadida L., Boukerrou N., Chiesa P., Colliot O., Dubois M., Epelbaum S., Gagliardi G., Genthon R., Houot M., Kas A., Lamari F., Levy M., Metzinger C., Mochel F., Nyasse F., Poisson C., Revillon M., Santos A., Andrade K. S., Sole M., Surtee M., de Schotten M. T., Younsi N., Afshar M., Aguilar L. F., Akman-Anderson L., Arenas J., Avila J., Babiloni C., Baldacci F., Batrla R., Benda N., Black K. L., Bokde A. L. W., Bonuccelli U., Broich K., Cacciola F., Caraci F., Castrillo J., Ceravolo R., Corvol J. -C., Cuello A. C., Cummings J. L., Depypere H., Duggento A., Emanuele E., Escott-Price V., Federoff H., Ferretti M. T., Fiandaca M., Frank R. A., Garaci F., Geerts H., Giorgi F. S., Goetzl E. J., Graziani M., Haberkamp M., Herholz K., Hernandez F., Kapogiannis D., Karran E., Kiddle S. J., Kim S. H., Koronyo Y., Koronyo-Hamaoui M., Langevin T., Lehericy S., Lucia A., Lorenceau J., Mango D., Mapstone M., Neri C., Nistico R., O'Bryant S. E., Palermo G., Perry G., Ritchie C., Rossi S., Saidi A., Santarnecchi E., Schneider L. S., Sporns O., Toschi N., Verdooner S. R., Villain N., Welikovitch L. A., Woodcock J., Younesi E. |
| المساهمون: | Chiesa, P. A., Cavedo, E., Vergallo, A., Lista, S., Potier, M. -C., Habert, M. -O., Dubois, B., Thiebaut de Schotten, M., Hampel, H., Bakardjian, H., Benali, H., Bertin, H., Bonheur, J., Boukadida, L., Boukerrou, N., Chiesa, P., Colliot, O., Dubois, M., Epelbaum, S., Gagliardi, G., Genthon, R., Houot, M., Kas, A., Lamari, F., Levy, M., Metzinger, C., Mochel, F., Nyasse, F., Poisson, C., Revillon, M., Santos, A., Andrade, K. S., Sole, M., Surtee, M., de Schotten, M. T., Younsi, N., Afshar, M., Aguilar, L. F., Akman-Anderson, L., Arenas, J., Avila, J., Babiloni, C., Baldacci, F., Batrla, R., Benda, N., Black, K. L., Bokde, A. L. W., Bonuccelli, U., Broich, K., Cacciola, F., Caraci, F., Castrillo, J., Ceravolo, R., Corvol, J. -C., Cuello, A. C., Cummings, J. L., Depypere, H., Duggento, A., Emanuele, E., Escott-Price, V., Federoff, H., Ferretti, M. T., Fiandaca, M., Frank, R. A., Garaci, F., Geerts, H., Giorgi, F. S., Goetzl, E. J., Graziani, M., Haberkamp, M., Herholz, K., Hernandez, F., Kapogiannis, D., Karran, E., Kiddle, S. J., Kim, S. H., Koronyo, Y., Koronyo-Hamaoui, M., Langevin, T., Lehericy, S., Lucia, A., Lorenceau, J., Mango, D., Mapstone, M., Neri, C., Nistico, R., O'Bryant, S. E., Palermo, G., Perry, G., Ritchie, C., Rossi, S., Saidi, A., Santarnecchi, E., Schneider, L. S., Sporns, O., Toschi, N., Verdooner, S. R., Villain, N., Welikovitch, L. A., Woodcock, J. |
| بيانات النشر: | Elsevier Inc. STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA |
| سنة النشر: | 2019 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Alzheimer's disease, brain functional dynamic, fMRI, precision medicine, subjective memory complaints |
| الوصف: | Introduction: The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods: In a large-scale monocentric cohort of 224 amyloid stratified individuals at risk for Alzheimer's disease, default mode network (DMN) resting state functional connectivity (FC) was investigated between two serial time points across 2 years. Results: Widespread DMN FC changes were shown in frontal and posterior areas, as well as in the right hippocampus. There were no cross-sectional differences, however, apolipoprotein E ε4 (APOE ε4) carriers demonstrated slower increase in FC in frontal lobes. There was no impact of individual brain amyloid load status. Discussion: For the first time, we demonstrated that the pleiotropic biological effect of the APOE ε4 allele impacts the dynamic trajectory of the DMN during aging. Dynamic functional biomarkers may become useful surrogate outcomes for the development of preclinical targeted therapeutic interventions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31113760; info:eu-repo/semantics/altIdentifier/wos/WOS:000475846300009; volume:15; issue:7; firstpage:940; lastpage:950; numberofpages:11; journal:ALZHEIMER'S & DEMENTIA; http://hdl.handle.net/11573/1407337Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85065804629 |
| DOI: | 10.1016/j.jalz.2019.03.006 |
| الإتاحة: | https://doi.org/10.1016/j.jalz.2019.03.006Test http://hdl.handle.net/11573/1407337Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.73C5C1B6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jalz.2019.03.006 |
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