دورية أكاديمية
Overlap of genetic loci for central serous chorioretinopathy with age-related macular degeneration
| العنوان: | Overlap of genetic loci for central serous chorioretinopathy with age-related macular degeneration |
|---|---|
| المؤلفون: | Ramo, J., Abner, E., Dijk, E.H.C. van, Wang, X., Brinks, J., Nikopensius, T., Noukas, M., Marjonen, H., Silander, K., Jukarainen, S., Kiiskinen, T., Choi, S.H., Kajanne, R., Mehtonen, J., Palta, P., Lubitz, S.A., Kaarniranta, K., Sobrin, L., Kurki, M., Yzer, S., Ellinor, P.T., Esko, T., Daly, M.J., Hollander, A.I. den, Palotie, A., Turunen, J.A., Boon, C.J.F., Rossin, E.J., Estonian Biobank Res Team |
| المصدر: | JAMA Ophthalmology |
| سنة النشر: | 2023 |
| المجموعة: | Leiden Repository (Leiden University) |
| الوصف: | IMPORTANCE Central serous chorioretinopathy (CSC) is a serous maculopathy of unknown etiology. Two of 3 previously reported CSC genetic risk loci are also associated with AMD. Improved understanding of CSC genetics may broaden our understanding of this genetic overlap and unveil mechanisms in both diseases.OBJECTIVE To identify novel genetic risk factors for CSC and compare genetic risk factors for CSC and AMD.DESIGN, SETTING, AND PARTICIPANTS Using International Classification of Diseases, Ninth (ICD-9) and Tenth (ICD-10) Revision code-based inclusion and exclusion criteria, patients with CSC and controls were identified in both the FinnGen study and the Estonian Biobank (EstBB). Also included in ameta-analysis were previously reported patients with chronic CSC and controls. Data were analyzed from March 1 to September 31, 2022.MAIN OUTCOMES AND MEASURES Genome-wide association studies (GWASs) were performed in the biobank-based cohorts followed by ameta-analysis of all cohorts. The expression of genes prioritized by the polygenic priority score and nearest-gene methods were assessed in cultured choroidal endothelial cells and public ocular single-cell RNA sequencing data sets. The predictive utility of polygenic scores (PGSs) for CSC and AMD were evaluated in the FinnGen study.RESULTS A total of 1176 patients with CSC and 526 787 controls (312 162 female [59.3%]) were included in this analysis: 552 patients with CSC and 343 461 controls were identified in the FinnGen study, 103 patients with CSC and 178 573 controls were identified in the EstBB, and 521 patients with chronic CSC and 3577 controls were included in ameta-analysis. Two previously reported CSC risk loci were replicated (near CFH and GATA5) and 3 novel loci were identified (near CD34/46, NOTCH4, and PREX1). The CFH and NOTCH4 loci were associated with AMD but in the opposite direction. Prioritized genes showed increased expression in cultured choroidal endothelial cells compared with other genes in the loci (median [IQR] of log 2 [counts per ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2803847Test; lumc-id: 185508215; https://hdl.handle.net/1887/3764037Test |
| DOI: | 10.1001/jamaophthalmol.2023.0706 |
| الإتاحة: | https://doi.org/10.1001/jamaophthalmol.2023.0706Test https://hdl.handle.net/1887/3764037Test https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2803847Test |
| رقم الانضمام: | edsbas.73910B46 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamaophthalmol.2023.0706 |
|---|