دورية أكاديمية
Periostin modulates extracellular matrix behavior in tendons
| العنوان: | Periostin modulates extracellular matrix behavior in tendons |
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| المؤلفون: | Kevin I. Rolnick, Joshua A. Choe, Ellen M. Leiferman, Jaclyn Kondratko-Mittnacht, Anna E.B. Clements, Geoffrey S. Baer, Peng Jiang, Ray Vanderby, Connie S. Chamberlain |
| المصدر: | Matrix Biology Plus, Vol 16, Iss , Pp 100124- (2022) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Periostin, Tendon, Scar, Healing, Collagen, Wound, Biology (General), QH301-705.5 |
| الوصف: | Periostin, originally named osteoblast-specific factor 2 (OSF-2) has been identified primarily in collagen rich, biomechanically active tissues where its role has been implicated in mechanisms to maintain the extracellular matrix (ECM), including collagen fibrillogenesis and crosslinking. It is well documented that periostin plays a role in wound healing and scar formation after injury, in part, by promoting cell proliferation, myofibroblast differentiation, and/or collagen fibrillogenesis. Given the significance of periostin in other scar forming models, we hypothesized that periostin will influence Achilles tendon healing by modulating ECM production. Therefore, the objective of this study was to elucidate the effects of periostin during Achilles tendon healing using periostin homozygous (Postn−/−) and heterozygous (Postn+/-) mouse models. A second experiment was included to further examine the influence of periostin on collagen composition and function using intact dorsal tail tendons. Overall, Postn−/− and Postn+/- Achilles tendons exhibited impaired healing as demonstrated by delayed wound closure, increased type III collagen production, decreased cell proliferation, and reduced tensile strength. Periostin ablation also reduced tensile strength and stiffness, and altered collagen fibril distribution in the intact dorsal tail tendons. Achilles tendon outcomes support our hypothesis that periostin influences healing, while tail tendon results indicate that periostin also affects ECM morphology and behavior in mouse tendons. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2590-0285 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2590028522000242Test; https://doaj.org/toc/2590-0285Test; https://doaj.org/article/9ad8a759e488458380b9c72a0697f66aTest |
| DOI: | 10.1016/j.mbplus.2022.100124 |
| الإتاحة: | https://doi.org/10.1016/j.mbplus.2022.100124Test https://doaj.org/article/9ad8a759e488458380b9c72a0697f66aTest |
| رقم الانضمام: | edsbas.7353F0E5 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 25900285 |
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| DOI: | 10.1016/j.mbplus.2022.100124 |