دورية أكاديمية
Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (Olea europaea, Mainly Cultivar coratina): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis
| العنوان: | Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (Olea europaea, Mainly Cultivar coratina): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis |
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| المؤلفون: | Recinella, Lucia, Micheli, Laura, Chiavaroli, Annalisa, Libero, Maria Loreta, Orlando, Giustino, Menghini, Luigi, Acquaviva, Alessandra, Di Simone, Simonetta, Ferrante, Claudio, Ghelardini, Carla, Brunetti, Luigi, Leone, Sheila |
| المساهمون: | Recinella, Lucia, Micheli, Laura, Chiavaroli, Annalisa, Libero, Maria Loreta, Orlando, Giustino, Menghini, Luigi, Acquaviva, Alessandra, Di Simone, Simonetta, Ferrante, Claudio, Ghelardini, Carla, Brunetti, Luigi, Leone, Sheila |
| سنة النشر: | 2022 |
| المجموعة: | ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| مصطلحات موضوعية: | Cultivar coratina, inflammation, osteoarthriti, hydroxytyrosol, pain |
| الوصف: | MOMAST® GR25 is a polyphenolic granular complex from olive pressing juice with high total content in polyphenols. In this work, we evaluated the possible anti-inflammatory effects of MOMAST® GR25 in both acute and chronic inflammatory models. MOMAST® GR25 decreased the levels of prostaglandin (PG) E2 and 8-iso-PGF2α in isolated rat colon, liver, and heart specimens stimulated with lipopolysaccharide (LPS). In vivo, compared to controls, rats treated with MOMAST® GR25 (100 mg/kg to 1 g/kg) showed a significant reduction in both licking/biting time in the formalin test. In a rat model of osteoarthritis by monoiodoacetate (MIA) injection, MOMAST® GR25 showed pain-relieving properties when acutely administered, reducing mechanical hyperalgesia and spontaneous pain. Moreover, a repeated daily treatment with MOMAST® GR25 (300 mg/kg) fully counteracted osteoarticular pain without the development of tolerance to the antinociceptive effect. Taken together, our present findings showed that MOMAST® GR25 could represent a potential strategy for the treatment of inflammation and pain. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35406100; info:eu-repo/semantics/altIdentifier/wos/WOS:000780580900001; volume:14; issue:7; firstpage:1487; journal:NUTRIENTS; http://hdl.handle.net/11564/774351Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85127374446; https://www.mdpi.com/2072-6643/14/7/1487Test |
| DOI: | 10.3390/nu14071487 |
| الإتاحة: | https://doi.org/10.3390/nu14071487Test http://hdl.handle.net/11564/774351Test https://www.mdpi.com/2072-6643/14/7/1487Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7335652A |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu14071487 |
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