دورية أكاديمية
Occupation, occupational exposures and mammographic density in Spanish women
| العنوان: | Occupation, occupational exposures and mammographic density in Spanish women |
|---|---|
| المؤلفون: | Jiménez, Tamara, García-Pérez, Javier, van der Haar, Rudolf, Alba, Miguel Ángel, de Lucas, Maria Pilar, Sierra, Maria Angeles, Fernandez de Larrea-Baz, Nerea, Salas-Trejo, Dolores, Llobet, Rafael, Martínez, Inmaculada, Pino, Marina Nieves, Alguacil, Juan, González-Galarzo, Mª Carmen, Martínez-Cortés, Mercedes, Perez-Gomez, Beatriz, Pollan-Santamaria, Marina, Lope Carvajal, Virginia |
| المساهمون: | Instituto de Salud Carlos III |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Breast density, Occupation, Chemical agents, Physical agents, Job-exposure matrix, DDM-Madrid, Breast Neoplasms, Occupational Exposure, Adult, Cross-Sectional Studies, Female, Humans, Mammography, Middle Aged, Occupations, Risk Factors |
| الوصف: | Introduction: Mammographic density (MD), the proportion of radiologically dense breast tissue, is a strong risk factor for breast cancer. Our objective is to investigate the influence of occupations and occupational exposure to physical, chemical, and microbiological agents on MD in Spanish premenopausal women. Methods: This is a cross-sectional study based on 1362 premenopausal workers, aged 39-50, who attended a gynecological screening in a breast radiodiagnosis unit of Madrid City Council. The work history was compiled through a personal interview. Exposure to occupational agents was evaluated using the Spanish job-exposure matrix MatEmESp. MD percentage was assessed using the validated semi-automated computer tool DM-Scan. The association between occupation, occupational exposures, and MD was quantified using multiple linear regression models, adjusted for age, educational level, body mass index, parity, previous breast biopsies, family history of breast cancer, energy intake, use of oral contraceptives, smoking, and alcohol consumption. Results: Although no occupation was statistically significantly associated with MD, a borderline significant inverse association was mainly observed in orchard, greenhouse, nursery, and garden workers (β = -6.60; 95% confidence interval (95%CI) = -14.27; 1.07) and information and communication technology technicians (β = -7.27; 95%CI = -15.37; 0.84). On the contrary, a positive association was found among technicians in art galleries, museums, and libraries (β = 8.47; 95%CI = -0.65; 17.60). Women occupationally exposed to fungicides, herbicides, and insecticides tended to have lower MD. The percentage of density decreased by almost 2% for every 5 years spent in occupations exposed to the mentioned agents. Conclusions: Although our findings point to a lack of association with the occupations and exposures analyzed, this study supports a deeper exploration of the role of certain occupational agents in MD, such as pesticides. ; This work was supported by the Carlos III ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0013-9351 1096-0953 |
| العلاقة: | https://doi.org/10.1016/j.envres.2021.110816Test; info:eu-repo/grantAgreement/ES/PI15CIII/0029; info:eu-repo/grantAgreement/ES/PI15CIII/00013; Environ Res. 2021 Apr:195:110816.; http://hdl.handle.net/20.500.12105/18537Test; Environmental research |
| DOI: | 10.1016/j.envres.2021.110816 |
| الإتاحة: | https://doi.org/20.500.12105/18537Test https://doi.org/10.1016/j.envres.2021.110816Test https://hdl.handle.net/20.500.12105/18537Test |
| حقوق: | http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; open access |
| رقم الانضمام: | edsbas.7311E38D |
| قاعدة البيانات: | BASE |
| تدمد: | 00139351 10960953 |
|---|---|
| DOI: | 10.1016/j.envres.2021.110816 |