التفاصيل البيبلوغرافية
| العنوان: |
Magnetocardiography at rest predicts cardiac death in patients with acute chest pain |
| المؤلفون: |
Wessel, N., Kim, J. S., Joung, B. Y., Ko, Y. G., Dischl, D., Gapelyuk, A., Lee, Y. H., Kim, K. W., Park, J. W., Landmesser, U. |
| المصدر: |
Frontiers in Cardiovascular Medicine ; volume 10 ; ISSN 2297-055X |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Cardiology and Cardiovascular Medicine |
| الوصف: |
Introduction Sudden cardiac arrest is a major cause of morbidity and mortality worldwide and remains a major public health problem for which better non-invasive prediction tools are needed. Primary preventive therapies, such as implantable cardioverter defibrillators, are not personalized and not predictive. Most of these devices do not deliver life-saving therapy during their lifetime. The individual relationship between fatal arrhythmias and cardiac function abnormalities in predicting cardiac death risk has rarely been explored. Methods We retrospectively analyzed the measurements at rest for 191 patients with acute chest pain (ACP) magnetocardiographically. Our recently introduced analyses are able to detect inhomogeneities of the depolarization and repolarization. Moreover, electrically silent phenomena—intracellular ionic currents as well as vortex currents—can be measured and quantified. All included ACP patients were recruited in 2009 at Yonsei University Hospital and were followed up until 2022. Results During half of the follow-up period (6.5 years), 11 patients died. Out of all the included nine clinical, eight magnetocardiographical, and nine newly introduced magnetoionographical parameters we tested in this study, three parameters revealed themselves to be outstanding at predicting death: heart rate-corrected QT (QTc) prolongation, depression of repolarization current I Kr + I Ks , and serum creatinine (all significant in Cox regression, p < 0.05). They clearly predicted cardiac death over the 6.5 years duration (sensitivity 90.9%, specificity 85.6%, negative predictive accuracy 99.4%). Cardiac death risk was more than ninefold higher in patients with low repolarization reserve and QTc prolongation in comparison with the remaining patients with ACP ( p < 0.001). The non-parametric Kaplan–Meier statistics estimated significantly lower survival functions from their lifetime data ( p < 0.001). Discussion To the best of our knowledge, these are the first data linking ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fcvm.2023.1258890 |
| DOI: |
10.3389/fcvm.2023.1258890/full |
| الإتاحة: |
https://doi.org/10.3389/fcvm.2023.1258890Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.731130EB |
| قاعدة البيانات: |
BASE |
