دورية أكاديمية
A cross sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study
| العنوان: | A cross sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study |
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| المؤلفون: | Millgate, Edward, Kravariti, Eugenia, Egerton, Alice, Howes, Oliver, Murray, Robin, Kassoumeri, Laura, Donocik, Jacek, Lewis, Shon, Drake, Richard, Lawrie, Stephen, Murphy, Anna, Collier, Tracy, Lees, Jane, Stockton-Powdrell, Charlotte, Walters, James, Deakin, Bill, MacCabe, James |
| بيانات النشر: | BMJ Publishing Group |
| سنة النشر: | 2021 |
| المجموعة: | Cardiff University: ORCA (Online Research @ Cardiff) |
| الوصف: | Background 70%–84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizophrenia has indicated that verbal memory and language functions may be more impaired in treatment resistance. We sought to confirm this finding by comparing cognitive performance between antipsychotic non-responders (NR) and responders (R) using a brief cognitive battery for schizophrenia, with a primary focus on verbal tasks compared against other measures of cognition. Design Cross-sectional. Setting This cross-sectional study recruited antipsychotic treatment R and antipsychotic NR across four UK sites. Cognitive performance was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS). Participants One hundred and six participants aged 18–65 years with a diagnosis of schizophrenia or schizophreniform disorder were recruited according to their treatment response, with 52 NR and 54 R cases. Outcomes Composite and subscale scores of cognitive performance on the BACS. Group (R vs NR) differences in cognitive scores were investigated using univariable and multivariable linear regressions adjusted for age, gender and illness duration. Results Univariable regression models observed no significant differences between R and NR groups on any measure of the BACS, including verbal memory (ß=−1.99, 95% CI −6.63 to 2.66, p=0.398) and verbal fluency (ß=1.23, 95% CI −2.46 to 4.91, p=0.510). This pattern of findings was consistent in multivariable models. Conclusions The lack of group difference in cognition in our sample is likely due to a lack of clinical distinction between our groups. Future investigations should aim to use machine learning methods using longitudinal first episode samples to identify responder subtypes within schizophrenia, and how cognitive factors may interact within this. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://orca.cardiff.ac.uk/id/eprint/144685/2/e054160.full.pdfTest; Millgate, Edward, Kravariti, Eugenia, Egerton, Alice, Howes, Oliver, Murray, Robin, Kassoumeri, Laura, Donocik, Jacek, Lewis, Shon, Drake, Richard, Lawrie, Stephen, Murphy, Anna, Collier, Tracy, Lees, Jane, Stockton-Powdrell, Charlotte, Walters, James https://orca.cardiff.ac.uk/view/cardiffauthors/A0230062.htmlTest orcid:0000-0002-6980-4053 orcid:0000-0002-6980-4053, Deakin, Bill and MacCabe, James 2021. A cross sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study. BMJ Open 11 , e054160. 10.1136/bmjopen-2021-054160 https://doi.org/10.1136/bmjopen-2021-054160Test file https://orca.cardiff.ac.uk/id/eprint/144685/2/e054160.full.pdfTest |
| DOI: | 10.1136/bmjopen-2021-054160 |
| الإتاحة: | https://doi.org/10.1136/bmjopen-2021-054160Test https://orca.cardiff.ac.uk/id/eprint/144685Test/ https://orca.cardiff.ac.uk/id/eprint/144685/2/e054160.full.pdfTest |
| حقوق: | cc_by |
| رقم الانضمام: | edsbas.72B0FD88 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjopen-2021-054160 |
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