دورية أكاديمية
Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin
| العنوان: | Selective autophagy, lipophagy and mitophagy, in the Harderian gland along the oestrous cycle: a potential retrieval effect of melatonin |
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| المؤلفون: | García-Macia, Marina, Santos-Ledo, Adrián, Caballero, Beatriz, Rubio-González, Adrián, Luxán-Delgado, Beatriz de, Potes, Yaiza, Rodríguez-González, Susana M., Boga, José Antonio, Coto-Montes, Ana |
| المساهمون: | Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Universidad de Oviedo |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2019 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | Lysosomes, Macroautophagy, Mitophagy, Reproductive biology |
| الوصف: | Sexual dimorphism has been reported in many processes. However, sexual bias in favour of the use of males is very present in science. One of the main reasons is that the impact of hormones in diverse pathways and processes such as autophagy have not been properly addressed in vivo. The Harderian gland is a perfect model to study autophagic modulation as it exhibits important changes during the oestrous cycle. The aim of this study is to identify the main processes behind Harderian gland differences under oestrous cycle and their modulator. In the present study we show that redox-sensitive transcription factors have an essential role: NF-κB may activate SQSTM1/p62 in oestrus, promoting selective types of autophagy: mitophagy and lipophagy. Nrf2 activation in dioestrus, leads the retrieval phase and restoration of mitochondrial homeostasis. Melatonin’s receptors show higher expression in dioestrus, leading to decreases in pro-inflammatory mediators and enhanced Nrf2 expression. Consequently, autophagy is blocked, and porphyrin release is reduced. All these results point to melatonin as one of the main modulators of the changes in autophagy during the oestrous cycle. ; This work was supported by FISS18-PI17/02009, C0120R3166, C0245R4032 and BH182173. MG-M has a postdoctoral fellowship from the Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia, Innovación y Universidades. Financial support from the University of Oviedo is also acknowledged. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | Publisher's version; http://dx.doi.org/10.1038/s41598-019-54743-5Test; Sí; e-issn: 2045-2322; Scientific Reports 9: 18597 (2019); http://hdl.handle.net/10261/203816Test; http://dx.doi.org/10.13039/501100004587Test; http://dx.doi.org/10.13039/501100011033Test; http://dx.doi.org/10.13039/501100006382Test |
| DOI: | 10.1038/s41598-019-54743-5 |
| DOI: | 10.13039/501100004587 |
| DOI: | 10.13039/501100011033 |
| DOI: | 10.13039/501100006382 |
| الإتاحة: | https://doi.org/10.1038/s41598-019-54743-5Test https://doi.org/10.13039/501100004587Test https://doi.org/10.13039/501100011033Test https://doi.org/10.13039/501100006382Test http://hdl.handle.net/10261/203816Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.726E77F7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-019-54743-5 |
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