رسالة جامعية
Chemistry of gold nanoparticles radiosensitizing effect ; Chimie de l'effet radiosensibilisant des nanoparticules d'or
| العنوان: | Chemistry of gold nanoparticles radiosensitizing effect ; Chimie de l'effet radiosensibilisant des nanoparticules d'or |
|---|---|
| المؤلفون: | Shcherbakov, Viacheslav |
| المساهمون: | Institut de Chimie Physique (ICP), Institut de Chimie - CNRS Chimie (INC-CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay, Mehran Mostafavi |
| المصدر: | https://theses.hal.science/tel-03793338Test ; Catalysis. Université Paris-Saclay, 2022. English. ⟨NNT : 2022UPASF032⟩. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Radiosensitization, Gold nanoparticles, Radical, Catalysis, Radiosensibilisation, Nanoparticules d'or, Catalyse, [CHIM.CATA]Chemical Sciences/Catalysis |
| الوصف: | Gold nanoparticles (AuNPs) are a promising class of radiosensitizers, agents that increase radiotherapy efficacy. In 2004, it was demonstrated that (AuNPs) accelerated tumour size reduction in mice after radio treatment. The use of gold was motivated by the so-called dose enhancement effect. Since gold has a high atomic number (Z=79), it absorbs more energy at the keV range than water or soft-tissue, increasing the overall ionization of irradiated volume due to the emission of secondary electrons and photons. Later, in vivo and in vitro experiments showed that the dose enhancement effect could not explain the observed radiosensitization. Nowadays, the proposed mechanism of nanoparticle-induced radiosensitization includes different physical, chemical, and biological effects. However, there is no consensus on the exact mechanism. The chemical effects are usually associated with the increased formation of reactive oxygen species (ROS), such as hydroxyl radicals (•OH), superoxide radicals (O₂•⁻), and hydrogen peroxide (H₂O₂), in the presence of nanoparticles. The primary method to detect ROS in biological studies is the use of fluorescent dyes. It is based on the oxidation of a non-fluorescent molecule to a fluorescent one in the reaction with ROS, assuming that increase in fluorescent intensity is proportional to the increase in ROS concentration. However, a dye oxidation process is a multistep process that includes the formation of a variety of products (not only the fluorescent one). AuNPs possess catalytic activity, which can change reaction pathways. In the current work, we examined the idea of increased ROS production in the presence of AuNPs with and without the use of ionizing radiation. First, we studied the effect of AuNPs on water radiolysis by directly measuring solvated electron yields evolution in time using the picosecond pulse radiolysis technique. There was no increase in primary water radicals production in the presence of AuNPs of different sizes and at a concentration up to 3 mM of gold (600 µM/m ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| اللغة: | English |
| العلاقة: | NNT: 2022UPASF032; tel-03793338; https://theses.hal.science/tel-03793338Test; https://theses.hal.science/tel-03793338/documentTest; https://theses.hal.science/tel-03793338/file/101885_SHCHERBAKOV_2022_archivage.pdfTest |
| الإتاحة: | https://theses.hal.science/tel-03793338Test https://theses.hal.science/tel-03793338/documentTest https://theses.hal.science/tel-03793338/file/101885_SHCHERBAKOV_2022_archivage.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.72495BBF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |